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Tough female doctors treat an exclusively female clientele at the Rittenhouse Women's Clinic, tackling female-centric issues and trying to make the world a better place in a male-dominated society.

A woman dying of lung cancer claims to be Lu's long-lost sister; Andy suspects a 4-year-old girl is a victim of shaken baby syndrome.

Andy meets the teenage boy responsible for Milo's death; Lu becomes suspicious when an organ-transplant patient suffers from mysterious complications.

Dana treats a promising young figure skater with osteoporosis who is determined to compete in the Olympics; Lu is not thrilled with the father of Marc's new girlfriend.

After kicking her husband out of the house, Andy contemplates whether or not she should tell her daughters about his abusive behavior.

Dr. Andy Campbell joins the Rittenhouse Women's Health Center as Lu's new partner; on Andy's unofficial first day, she clashes with Lu over a woman who had an illegal kidney transplant and a patient of Lu's who refuses to get her young son vaccinated.

Dr. Jackson finds himself in hot water after denying a job to a overweight woman; Dana treats a patient who is diagnosed with Gulf War Syndrome; Lana cares for an abandoned newborn baby.

Lu fears that her unborn child might have a fatal genetic condition and defends a pregnant mother who is accused of welfare fraud.

The parents of conjoined twin daughters refuse to have them separated; Lu suspects that a woman diagnosed with leukemia intentionally started a fire.

Lu, Peter, and Lana host a dance-a-thon and a free mammogram clinic for Breast Cancer Awareness weekend; Lu tries to intervene to help a patient keep her breast and her job after her mammogram reveals a lump; Dana gets some unexpected results of her breast cancer clinical trial and learns that her mother has breast cancer.

Dr. Stowe's mother struggles with her diagnosis with Dana's helping hand. Lu offers to help with her schedule with some amusing results.

Kayla loses a patient who was a bank robber, only for his unstable girlfriend Jamie to show up at the hospital with a bomb strapped to her body. Meanwhile, 35-week pregnant Sirena Adkins is brought in suffering from meningitis and her mom tells Lu to only save the daughter and not the baby.

Andy fights for the rights to an organ from a liver transplant; Lu helps out a woman whose husband has just been released from prison; Nick treats a paramedic who was stuck with a needle from a drug addict.

Lu treats a young college woman with meningitis; meanwhile, Dana develops symptoms which suggest that she might be pregnant.

Lu discovers that two teenage girls have been poisoned by a girl at their high school they have bullied; a patient of Andy asks her to endorse her new heart-health diet book only to end up in the emergency room suffering from a heart attack.

Dana tries to figure out how a virginal young woman got pregnant; Lu cares for a hospital employee who is diagnosed with Lou Gehrig's disease.

Andy diagnoses a woman with West Nile virus; Lu tries to help out a woman and her hospital-bound son.

Lu helps out a woman with carpal tunnel syndrome whose job won't cover her medical condition; Dana treats a pregnant woman and her teenage son for lead poisoning.

A patient of Andy's seeks help to stop her chronic blushing; Lu is unsure about whether or not she should prescribe a painkiller to a recovering drug addict.

Lu treats a female acquaintance of Marc's who is discovered to be pregnant and claims that Marc is the father; Andy becomes a health food advocate at Lizzie's school; Kayla asks Peter to pose as her fiance when her ex-boyfriend comes to town.

Lu discovers that one of Marc's friends is an alcoholic; a patient of Dana's who has Parkinson's wants to undergo an experimental procedure involving aborted fetal cells.

Lu suspects that a young girl's asthma is caused by the stress of her bickering parents; Andy suspects her nanny of theft which turns out to be orchestrated by her daughter Lizzie who was trying to get her parents back together.

Lu helps out a teenage girl who wants to get out of the gang life; Dylan fights to get a young woman with Down Syndrome a heart transplant.

Andy and Milo are invited to stay in a beach-side cabin owned by a patient of Andy's at Cape June, a beach-side vacation community. The vacation gets interrupted when a young boy suddenly becomes very ill with similar symptoms to Andy's patient who has cancer. Andy is further shocked to learn that 9 other residents of the town have died from cancer.

Kayla competes with a fellow male colleague to get the job of chief resident; Lu deals with a teenaged patient who wants to be emancipated so she doesn't have to donate a kidney to her sister.

A mother believes that the medication Lu prescribed for her autistic daughter is helping her speak; Dana is torn between a patient's husband and mother about taking the patient off life support.

In the series' 100th episode, an adoptive mother and a biological mother fight over the custody of a young girl; a patient of Andy sues her insurance company when she is diagnosed with cancer too late.

Lu becomes personally involved when her patient's 11-year-old son is tased with a stun gun at school; Dylan treats a patient with a rare form of multiple sclerosis; Kayla suspects that a patient of hers was exposed to ricin.

Andy is considered for the position of Chief of Surgery; Lu deals with a drug company who wants to financially compensate her leukemia patient.

When Andy encounters a young woman with amnesia and her fiance, she must decide which secrets should remain untold. Meanwhile, when a pregnant patient refuses to stop using drugs, Lu faces an ethical dilemma and must decide whether to intervene.

Lu treats a female prisoner who is diagnosed with cervical cancer; Dana is asked to perform a risky surgical procedure on an unborn child.

Lu treats a 12-year-old girl with gonorrhea who accuses her teacher of giving her the disease; Dana discovers that two of her pregnant patients unknowingly have the same father.

Andy treats a woman who has a history of miscarriages; Lu treats a patient's heroin addiction by using a new anti-opiate drug.

Dr. Jackson asks Dana to try a new experimental drug on his wife who has multiple sclerosis; Lu treats a young woman with anorexia.

Jonas reveals news that could affect his relationship with Lu; Andy leaves Rittenhouse to become the new surgeon general.

When Lu's mentor misdiagnoses a patient, Lu contemplates whether or not to tell her that she needs to retire; Andy treats a couple's two young daughters who are diagnosed with a rare genetic disorder; Andy's daughter, Jesse faces bullying over her back brace.

Lu treats a young orphaned boy with attention deficit disorder and discovers that his foster guardian has been using the Ritalin that she prescribed to him; Dana helps the wife of a high-powered real estate developer who has been abusing her.

Andy becomes suspicious when three patients of hers who underwent surgery suffer from complications; meanwhile, Lu treats a pregnant woman who might have been exposed to chicken pox.

When a mother's two children are suffering from kidney failure, she has to make a choice about which child to donate a kidney to; Dylan's college mentor ends up being hospitalized for a debilitating neurological disorder.

Dana decides to leave Rittenhouse to care for an HIV-positive baby and her older sister full time; Lu treats a homeless woman suffering from epilepsy.

After a councilwoman comes to the clinic to see Dana a few gang members are upset when they are unable to get insurance and the councilwoman refuses to listen. Seconds later, an unknown gunman begins shooting at the clinic which accidentally injures the councilwoman; Peter treats a woman who was traumatized during the shooting and learns that she grew up in Cambodia during the war, but soon discovers the real source of her pain.

Lu and Dana butt heads over a deceased young woman's fertilized eggs; a dying patient of Lu is in need of a heart transplant; Peter's mother pays a visit.

Lu and Dylan face an ethical dilemma when it comes to using an experimental drug on a patient with Parkinson's disease; Lu treats a deaf woman who was injured in an accident; Kayla treats patients from a circus suffering from tuberculosis.

Dana is shocked when Dr. Jackson's wife, Susan comes into the ER with bruises which at first she thinks that Robert gave them to her, but Susan is later diagnosed with multiple sclerosis; Lu deals with Marc's mugging at school and a group of drug-addicted prostitutes who want their tubes tied for money.

Dana cares for a priest who has been disguising herself as a man; Lu prescribes a drug for a woman diagnosed with sickle cell anemia whose pharmacist won't carry it for fear of his store being robbed.

When two teenagers are diagnosed with Legionnaires' disease, Dylan tries to find out how they contracted the disease; while volunteering at a women's prison, Lu fights to get adequate health care for the prisoners.

Andy cares for a princess from a foreign country whose family wants her to have surgery to fix her deformity so she can be ready for an arranged marriage and is approached by a woman who wants to regain her virginity before she gets married; Lu helps out a woman with Alzheimer's cope with her tragic past.

Lu's past comes back to haunt her after her rapist, Dr. Kilner is brought to the emergency room with heart issues.

Lu and Jonas' honeymoon is cut short when Lu brings a group of orphaned children from Costa Rica to Rittenhouse for medical treatment, but Jonas finds himself being charged with embezzlement; Kayla suspects a mother of making her son sick.

Dylan treats a woman suffering from heroin addiction; Lu treats a little girl who has a rare medical condition that doesn't allow her to feel pain.