“I worked with him under Christ hope international Zambia, when he came to Zambia. at that time he was a student at kelvin college.”
Activity
-
Appropriately dressed for a panel at our JPMorganChase Expert Engineer program in Glasgow this week. Great to meet this year’s cohort and have the…
Appropriately dressed for a panel at our JPMorganChase Expert Engineer program in Glasgow this week. Great to meet this year’s cohort and have the…
Liked by Chase Hulderman
-
I wish demoing at conferences was more about "show them how to solve a problem with the tool" over "how can I sell this person the tool". I do a lot…
I wish demoing at conferences was more about "show them how to solve a problem with the tool" over "how can I sell this person the tool". I do a lot…
Liked by Chase Hulderman
-
Another trip to India in the books, this one might be the winner and I think it’s my 43rd so it’s a high bar! What we are doing with agentic AI to…
Another trip to India in the books, this one might be the winner and I think it’s my 43rd so it’s a high bar! What we are doing with agentic AI to…
Liked by Chase Hulderman
Experience
Education
Licenses & Certifications
Volunteer Experience
-
President
Student Government Association - Rutgers Medical School
- 1 year
Education
Provided oversight for all student organizations and developed new initiatives. Organized board and general meetings. Administered existing activities, programs, and budgets.
-
Student Doctor
The Promise Clinic
- 1 year 10 months
Provided healthcare for the local indigent and homeless in New Brunswick, NJ as part of a team of medical students.
-
Steering Committee
The Promise Clinic
- 1 year 11 months
Health
Facilitated communication between subcommittees. Implemented collection of quality metrics and improved clinic efficiency and effectiveness. Designed and created the clinic’s annual report.
Publications
-
Substituent effects on the amination of racemic allyl carbonates using commercially available chiral rhodium catalysts
Tetrahedron Letters
In the presence of commercially available chiral rhodium catalysts, a competitive benzylamination of racemic allyl carbonates, substituted with p-X-Ph groups, shows that the reaction proceeds faster with substituents (X) that are more electron-withdrawing. Mechanistic implications of these results are discussed.
Other authorsSee publication -
RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
PNAS
Neuroblastoma is a childhood cancer that is often fatal despite intense multimodality therapy. In an effort to identify therapeutic targets for this disease, we performed a comprehensive loss-of-function screen of the protein kinome. Thirty kinases showed significant cellular cytotoxicity when depleted, with loss of the cell cycle checkpoint kinase 1 (CHK1/CHEK1) being the most potent. CHK1 mRNA expression was higher in MYC-Neuroblastoma-related (MYCN)-amplified (P < 0.0001) and high-risk (P…
Neuroblastoma is a childhood cancer that is often fatal despite intense multimodality therapy. In an effort to identify therapeutic targets for this disease, we performed a comprehensive loss-of-function screen of the protein kinome. Thirty kinases showed significant cellular cytotoxicity when depleted, with loss of the cell cycle checkpoint kinase 1 (CHK1/CHEK1) being the most potent. CHK1 mRNA expression was higher in MYC-Neuroblastoma-related (MYCN)-amplified (P < 0.0001) and high-risk (P = 0.03) tumors. Western blotting revealed that CHK1 was constitutively phosphorylated at the ataxia telangiectasia response kinase target site Ser345 and the autophosphorylation site Ser296 in neuroblastoma cell lines. This pattern was also seen in six of eight high-risk primary tumors but not in control nonneuroblastoma cell lines or in seven of eight low-risk primary tumors. Neuroblastoma cells were sensitive to the two CHK1 inhibitors SB21807 and TCS2312, with median IC(50) values of 564 nM and 548 nM, respectively. In contrast, the control lines had high micromolar IC(50) values, indicating a strong correlation between CHK1 phosphorylation and CHK1 inhibitor sensitivity (P = 0.0004). Furthermore, cell cycle analysis revealed that CHK1 inhibition in neuroblastoma cells caused apoptosis during S-phase, consistent with its role in replication fork progression. CHK1 inhibitor sensitivity correlated with total MYC(N) protein levels, and inducing MYCN in retinal pigmented epithelial cells resulted in CHK1 phosphorylation, which caused growth inhibition when inhibited. These data show the power of a functional RNAi screen to identify tractable therapeutical targets in neuroblastoma and support CHK1 inhibition strategies in this disease.
Other authorsSee publication
Recommendations received
1 person has recommended Chase
Join now to viewMore activity by Chase
-
JPMorganChase CEO Jamie Dimon criticized the mentality of people strictly “staying in their lane” at work, calling it a “bureaucratic, stupid…
JPMorganChase CEO Jamie Dimon criticized the mentality of people strictly “staying in their lane” at work, calling it a “bureaucratic, stupid…
Liked by Chase Hulderman
-
A practical optimization book Search, optimization, and machine learning are fundamental building blocks in many business problems. The…
A practical optimization book Search, optimization, and machine learning are fundamental building blocks in many business problems. The…
Liked by Chase Hulderman
-
Just finished the course “Agentic AI Fundamentals: Architectures, Frameworks, and Applications” by David Linthicum! Check it out:…
Just finished the course “Agentic AI Fundamentals: Architectures, Frameworks, and Applications” by David Linthicum! Check it out:…
Liked by Chase Hulderman
-
I don’t take enough time to reflect on my accomplishments and be proud of them. However today, on my 51st birthday, Im going to do just that. 51…
I don’t take enough time to reflect on my accomplishments and be proud of them. However today, on my 51st birthday, Im going to do just that. 51…
Liked by Chase Hulderman
-
What an incredible first week at Truist in the Atlanta office! I had the privilege of meeting amazing team members, learning about key processes…
What an incredible first week at Truist in the Atlanta office! I had the privilege of meeting amazing team members, learning about key processes…
Liked by Chase Hulderman
-
Today was a lovely morning to have breakfast with Stefano Peroni! It was a pleasure to have you in West Des Moines Iowa for some strategic…
Today was a lovely morning to have breakfast with Stefano Peroni! It was a pleasure to have you in West Des Moines Iowa for some strategic…
Liked by Chase Hulderman
-
Some obvious and not so obvious challenges of being a Principal Engineer Paradox of Belonging: You are part of all teams, yet you are part of none.…
Some obvious and not so obvious challenges of being a Principal Engineer Paradox of Belonging: You are part of all teams, yet you are part of none.…
Liked by Chase Hulderman
-
After an incredible journey at Wells Fargo, it's time for me to say farewell and embrace a new chapter. My tenure here has been filled with valuable…
After an incredible journey at Wells Fargo, it's time for me to say farewell and embrace a new chapter. My tenure here has been filled with valuable…
Liked by Chase Hulderman
-
I'm excited to announce that I have joined Broadridge as the Global Head of Application Security and Vulnerability Management. In this role, I'll be…
I'm excited to announce that I have joined Broadridge as the Global Head of Application Security and Vulnerability Management. In this role, I'll be…
Liked by Chase Hulderman
-
We're at #SREcon Americas! If you're attending, stop by Booth #7 to say hi 👋
We're at #SREcon Americas! If you're attending, stop by Booth #7 to say hi 👋
Liked by Chase Hulderman
-
I read through this great book by Bahaaldine A. and Jeff Vestal a year ago and i recently took it with me on holidays. What was remarkable was in…
I read through this great book by Bahaaldine A. and Jeff Vestal a year ago and i recently took it with me on holidays. What was remarkable was in…
Liked by Chase Hulderman
-
At Discover Financial Services, our collaborative efforts across functions shine as we not only meet consumer/partner expectations but also pave the…
At Discover Financial Services, our collaborative efforts across functions shine as we not only meet consumer/partner expectations but also pave the…
Liked by Chase Hulderman
Other similar profiles
Explore collaborative articles
We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
Explore More