Vesiculab’s Post

Designing a novel liposome system for multi-stage drug release: in their latest work,Yuval Elani at Imperial College London and collaborators have developed an innovative engineering strategy that integrates microfluidics and conjugation chemistry to create nanosized liposomes with dual discrete compartments, one nested within the other, which they call concentrisomes https://lnkd.in/eZirFw5G This approach has enabled the engineering of particles capable of multi-stage release and stimuli-responsive enzymatic synthesis within the particle. An article also authored by Colin Pilkington, Ignacio Gispert, PhD, @Suet Y. Chui and John Seddon #nanomedicine #liposomes #nanoparticles #microfluidics #Vesiculab

Uncover the Potential of Triazolopyrimidine Derivatives in Neuropathic Pain and Chronic Cough! In an exciting development published in the Journal of Medicinal Chemistry, a team of researchers led by Ga-Ram Kim et al., have discovered a new class of P2X3 receptor antagonists,  triazolopyrimidine derivatives. Utilizing cryo-electron microscopy, the research reveals that these compounds bind to a previously unknown allosteric site on the P2X3 receptor, stabilizing it in a desensitized state and effectively blocking ion channels. This breakthrough opens new avenues for developing treatments with fewer side effects. Read the full article here https://lnkd.in/e2smSbDv and order this revolutionizing compound from our stock: https://lnkd.in/e25dZxfN

As the identification of lipid nanoparticle aggregation is a key part of their development and production QC, the topic of particle size measurement and reporting becomes particularly relevant. So, how is particle size reported? Watch now in this short vid: https://hubs.la/Q02FM3_50

I am delighted to share the good news that our in-silico studies paper has been published in high impact journal "Chemical Physics Impact". I would like to thank our guide Dr. Trupti Chitre for her valuable guidance and all the co-authors for constant support. Title: Rational design of some 1,3,4 trisubstituted pyrazole-thiazole derivatives to serve as MtInhA inhibitors using QSAR, ADMET, molecular docking, MM-GBSA, and molecular dynamics simulations approach. Publication: Elsevier Impact Factor: 3.8 DOI: https://lnkd.in/g-fTeQEu #Insilicostudy #ComputationalStudy #MolecularDynamics #MolecularDocking

Join us for a webinar on Nanoparticle Characterization this Thursday, August 22nd, at 4 PM. The session will cover our advanced characterization services for lipid nanoparticles and virus-like particles. If you still need to register, you can do so here : https://wllw.co/DBZbpEV93 #structuralbiology #nanoparticles #lipidnanoparticles #viruslikeparticles

Structured protein domains are modulators of biomolecular condensate form and function Structured protein domains are pervasive within cellular biomolecular condensates. Two unique properties distinguish structured protein domains from disordered protein domains within condensates: high interaction specificity and low conformational heterogeneity. Through highly specific interactions – including protein-protein binding, oligomerization, and RNA-binding – structured protein domains can dictate condensate formation, material properties, and functions. A condensate’s chemical environment can cause conformational rearrangement or unfolding of structured protein domains, which in turn can inform condensate behavior and properties. A complete understanding of condensate biophysics will necessitate a thorough characterization of structured protein domains within condensates. #sciencenewshighlights #ScienceMission https://lnkd.in/gnH32xSR https://lnkd.in/gFH8h-Pn

Really pleased that my first article has been published in Analytical Chemistry. Hence, we develope a novel biosensing nanotechnology-based method for AβO determination in Alzheirmer's Patients. Its great performance allows a cheap, fast (5 minutes) and precise detection in ultra-low samples (5 µL). The Alzheimer Disease diagnosis is a huge challenge, althougth with this method we are closer to a decentralised blood-based sensor. "Gold Nanoparticle-Decorated Catalytic Micromotor-Based Aptassay for Rapid Electrochemical Label-Free Amyloid-β42 Oligomer Determination in Clinical Samples from Alzheimer’s Patients" https://lnkd.in/dRbWnVsR

Spectral flow cytometry continues to push the boundaries of multiparameter cell analysis, enabling researchers to delve deeper into cellular subsets and integrate results with high-performance cell sorting. Join our webinar on August 29th, as Dr. Andrew Draghi, II Ph.D., MS from Sony Biotechnology Inc. demonstrates the power of the FP7000 Spectral Cell Sorter. He’ll guide you through the design and analysis of 20+ color panels using the ID7000™ Spectral Cell Analyzer and show how to efficiently transition these panels to the FP7000 without the need for panel optimization or redesign - saving both time and reagents. Don’t miss this opportunity to learn how to design high-parameter spectral panels - register to attend the live event or catch the recording afterwards: https://lnkd.in/di-92wuQ #flowcytometry #spectral #spectralflowcytometry #cellanalysis #cellsorting

Excellent presentation

[𝗢𝗽𝗲𝗻 𝗔𝗰𝗰𝗲𝘀𝘀 𝗔𝗿𝘁𝗶𝗰𝗹𝗲 𝗛𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁 🌟] 𝐀 𝐏𝐢𝐩𝐞𝐫𝐚𝐳𝐢𝐧𝐞 𝐋𝐢𝐧𝐤𝐞𝐝 𝐑𝐡𝐨𝐝𝐚𝐦𝐢𝐧𝐞-𝐁𝐎𝐃𝐈𝐏𝐘 𝐅𝐑𝐄𝐓-𝐛𝐚𝐬𝐞𝐝 𝐅𝐥𝐮𝐨𝐫𝐞𝐬𝐜𝐞𝐧𝐭 𝐒𝐞𝐧𝐬𝐨𝐫 𝐟𝐨𝐫 𝐇𝐢𝐠𝐡𝐥𝐲 𝐒𝐞𝐥𝐞𝐜𝐭𝐢𝐯𝐞 𝐏𝐝𝟐+ 𝐚𝐧𝐝 𝐁𝐢𝐨𝐭𝐡𝐢𝐨𝐥 𝐃𝐞𝐭𝐞𝐜𝐭𝐢𝐨𝐧 (Chemistry – An Asian Journal, Volume18, Issue16) Ken Leung Department of Chemistry State Key Laboratory of Environmental and Biological Analysis, HKBU HKBU Faculty of Science 𝗔𝗯𝘀𝘁𝗿𝗮𝗰𝘁: A class of rhodamine-based fluorescent sensors for the selective and sensitive detection of Pd2+ metal ions in aqueous media has been developed. A rhodamine-based sensor PMS and a rhodamine-BODIPY Förster resonance energy transfer (FRET)-pair sensor PRS have been incorporated with a piperazine linker and an O−N−S−N podand ligand for specific recognition of Pd2+ ion. Both probes displayed colorimetric and fluorescent ratiometric changes when exposed to Pd2+, due to their spirolactam rings opening and restoring rhodamine conjugation. PRS is highly selective to Pd2+ over 22 other metal ions, showing a 0.6-fold ratiometric difference at I600nm/I515nm. Additionally, the lactam ring in Pd2+ coordinated PRS-Pd could be switched back to the closed form in the presence of various thiols, providing a “red-green traffic light” detection mechanism between red and green emission. Furthermore, PRS showed excellent cell viability and was successfully employed to image Pd2+ and the PRS-Pd complex ensemble could interchangeably detect biothiols including glutathione (GSH) in A549 human lung cancer cells. https://lnkd.in/gCaYuphV ⭐ 𝗠𝗮𝗱𝗲 𝗢𝗽𝗲𝗻 𝗔𝗰𝗰𝗲𝘀𝘀 𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝘁𝗵𝗲 𝗟𝗶𝗯𝗿𝗮𝗿𝘆’𝘀 𝗢𝗔 𝗣𝘂𝗯𝗹𝗶𝘀𝗵𝗶𝗻𝗴 𝗔𝗴𝗿𝗲𝗲𝗺𝗲𝗻𝘁 Learn about our OA Agreements: https://bit.ly/hkbuOA #chemistry #cancer #cell #lung #research #openaccess #article #science #hkbu #library