About: C286

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

C286, (4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl) benzoic acid) is a potent, orally bioavailable retinoic acid receptor beta (RARβ) agonist (EC50 = 1.9nM) with good selectivity over the RARα, and RARγ receptors. This molecule increases neurite outgrowth in vitro and stimulates sensory axon regrowth in vivo in a rodent model of crush and avulsion injury, and is being evaluated for the treatment of nerve injury.

Property	Value
dbo:abstract	C286, (4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl) benzoic acid) is a potent, orally bioavailable retinoic acid receptor beta (RARβ) agonist (EC50 = 1.9nM) with good selectivity over the RARα, and RARγ receptors. This molecule increases neurite outgrowth in vitro and stimulates sensory axon regrowth in vivo in a rodent model of crush and avulsion injury, and is being evaluated for the treatment of nerve injury. (en)
dbo:casNumber	1952276-71-9
dbo:fdaUniiCode	N8LRS5GBB6
dbo:pubchem	121414283
dbo:thumbnail	wiki-commons:Special:FilePath/Structure_of_C286.svg?width=300
dbo:wikiPageID	65588571 (xsd:integer)
dbo:wikiPageLength	8360 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1116680123 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Cytochrome_P450 dbr:Cytotoxicity dbc:Oxadiazoles dbr:Genotoxicity dbr:Neuropathic_pain dbr:Peripheral_nervous_system dbr:Lipophilicity dbr:Agonist dbr:Central_nervous_system dbr:Retinoic_acid_receptor_beta dbr:Retinoid_X_receptor dbc:Benzoic_acids dbc:Retinoids dbr:Bioavailability dbr:Remyelination dbr:Avulsion_injury dbr:Axon dbc:Benzofurans dbr:Neurons dbr:Neurite dbr:Retinoid dbr:Oxadiazole dbr:P-glycoprotein dbr:Microsomes dbr:File:Discovery_of_C286.svg dbr:File:Synthesis_of_C268.svg
dbp:c	19 (xsd:integer)
dbp:casNumber	1952276 (xsd:integer)
dbp:chemspiderid	88295952 (xsd:integer)
dbp:h	14 (xsd:integer)
dbp:iupacName	4 (xsd:integer)
dbp:n	2 (xsd:integer)
dbp:o	4 (xsd:integer)
dbp:pubchem	121414283 (xsd:integer)
dbp:smiles	CC1=C2C=CC3=NCC4=CC=CCO (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	AVCXUODHLRZJJP-UHFFFAOYSA-N (en)
dbp:unii	N8LRS5GBB6 (en)
dbp:wikiPageUsesTemplate	dbt:Infobox_drug dbt:Reflist dbt:Cascite dbt:Fdacite
dcterms:subject	dbc:Oxadiazoles dbc:Benzoic_acids dbc:Retinoids dbc:Benzofurans
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	C286, (4-(5-(4,7-dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl) benzoic acid) is a potent, orally bioavailable retinoic acid receptor beta (RARβ) agonist (EC50 = 1.9nM) with good selectivity over the RARα, and RARγ receptors. This molecule increases neurite outgrowth in vitro and stimulates sensory axon regrowth in vivo in a rodent model of crush and avulsion injury, and is being evaluated for the treatment of nerve injury. (en)
rdfs:label	C286 (en)
owl:sameAs	wikidata:C286 https://global.dbpedia.org/id/Fa1JU
prov:wasDerivedFrom	wikipedia-en:C286?oldid=1116680123&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Discovery_of_C286.svg wiki-commons:Special:FilePath/Structure_of_C286.svg wiki-commons:Special:FilePath/Synthesis_of_C268.svg
foaf:isPrimaryTopicOf	wikipedia-en:C286
is dbo:wikiPageWikiLink of	dbr:Glossary_of_chemical_formulae
is foaf:primaryTopic of	wikipedia-en:C286