About: D5SICS

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

d5SICS is an artificial nucleoside containing 6-methylisoquinoline-1-thione-2-yl group instead of a base. It pairs up with dNaM in a hydrophobic interaction. It was not able to be removed by the error-correcting machinery of the E. coli into which it was inserted. The pairing of d5SICS–dNaM is mediated by packing and hydrophobic forces instead of hydrogen bonding, which occurs in natural base pairs. Therefore, in free DNA, rings of d5SICS and dNaM are placed in parallel planes instead of the same plane. The d5SICS-dNaM pairing replaced an older dNaM- pairing.

Property	Value
dbo:abstract	d5SICS is an artificial nucleoside containing 6-methylisoquinoline-1-thione-2-yl group instead of a base. It pairs up with dNaM in a hydrophobic interaction. It was not able to be removed by the error-correcting machinery of the E. coli into which it was inserted. The pairing of d5SICS–dNaM is mediated by packing and hydrophobic forces instead of hydrogen bonding, which occurs in natural base pairs. Therefore, in free DNA, rings of d5SICS and dNaM are placed in parallel planes instead of the same plane. The d5SICS-dNaM pairing replaced an older dNaM- pairing. (en)
dbo:iupacName	2-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methylisoquinoline-1(2H)-thione (en) 2-(2-Deoxy-β-(D)-erythro-pentofuranosyl)-6-methylisoquinoline-1(2H)-thione (en)
dbo:thumbnail	wiki-commons:Special:FilePath/D5SICS-skeletal.png?width=300
dbo:wikiPageID	47378095 (xsd:integer)
dbo:wikiPageLength	3214 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1095862625 (xsd:integer)
dbo:wikiPageWikiLink	dbc:Thioketones dbr:Nucleoside dbc:Nitrogen_heterocycles dbc:Nucleosides dbc:Synthetic_biology dbr:DNaM dbr:E._coli dbr:Base_pair dbr:Ring_(chemistry) dbc:Heterocyclic_compounds_with_2_rings dbr:Isoquinoline dbr:Hydrogen_bonding dbr:Hydrophobic_force dbr:DTPT3
dbp:imagefile	D5SICS-skeletal.png (en) D5SICS.png (en)
dbp:imagename	Ball-and-stick model of d5SICS (en) Haworth projection of d5SICS (en)
dbp:iupacname	2 (xsd:integer)
dbp:name	d5SICS (en)
dbp:pin	2 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Chembox dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Lowercase_title dbt:Reflist dbt:Cascite dbt:Molecular-biology-stub
dcterms:subject	dbc:Thioketones dbc:Nitrogen_heterocycles dbc:Nucleosides dbc:Synthetic_biology dbc:Heterocyclic_compounds_with_2_rings
gold:hypernym	dbr:Nucleotide
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound
rdfs:comment	d5SICS is an artificial nucleoside containing 6-methylisoquinoline-1-thione-2-yl group instead of a base. It pairs up with dNaM in a hydrophobic interaction. It was not able to be removed by the error-correcting machinery of the E. coli into which it was inserted. The pairing of d5SICS–dNaM is mediated by packing and hydrophobic forces instead of hydrogen bonding, which occurs in natural base pairs. Therefore, in free DNA, rings of d5SICS and dNaM are placed in parallel planes instead of the same plane. The d5SICS-dNaM pairing replaced an older dNaM- pairing. (en)
rdfs:label	D5SICS (en)
owl:sameAs	yago-res:D5SICS wikidata:D5SICS https://global.dbpedia.org/id/2PBSG
prov:wasDerivedFrom	wikipedia-en:D5SICS?oldid=1095862625&ns=0
foaf:depiction	wiki-commons:Special:FilePath/D5SICS-skeletal.png wiki-commons:Special:FilePath/D5SICS.png
foaf:isPrimaryTopicOf	wikipedia-en:D5SICS
foaf:name	d5SICS (en)
is dbo:wikiPageRedirects of	dbr:C15H17NO3S
is dbo:wikiPageWikiLink of	dbr:Nucleic_acid_analogue dbr:Nucleotide dbr:Synthetic_biology dbr:C15H17NO3S dbr:Synthetic_genomics dbr:DNaM dbr:Base_pair dbr:Artificial_gene_synthesis dbr:Expanded_genetic_code
is foaf:primaryTopic of	wikipedia-en:D5SICS