About: Linomide

Property	Value
dbo:abstract	Linomide (Roquinimex) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity. It also inhibits angiogenesis and reduces the secretion of TNF alpha. Linomide has been investigated as a treatment for some cancers (including as adjuvant therapy after bone marrow transplantation in acute leukemia) and autoimmune diseases, such as multiple sclerosis and recent-onset type I diabetes. Several trials have been terminated due to serious cardiovascular toxicity. (en)
dbo:casNumber	84088-42-6
dbo:chEBI	92056
dbo:chEMBL	11672
dbo:drugbank	DB11366
dbo:fdaUniiCode	372T2944C0
dbo:kegg	D05756
dbo:pubchem	54676478
dbo:thumbnail	wiki-commons:Special:FilePath/Roquinimex.svg?width=300
dbo:wikiPageID	14230709 (xsd:integer)
dbo:wikiPageLength	4392 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1120108414 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Quinoline dbr:Natural_killer_cell dbr:Cytotoxicity dbc:3-Hydroxypropenals dbr:Multiple_sclerosis dbr:Leukemia dbr:Diabetes_mellitus_type_1 dbr:Tumor_necrosis_factor-alpha dbc:Carboxamides dbc:Quinolinols dbr:Angiogenesis dbc:2-Quinolones dbc:Anilides dbr:Hematopoietic_stem_cell_transplantation dbc:Immunostimulants dbr:Macrophage dbr:Immunostimulant dbr:N-methylaniline dbr:Ethyl_malonate dbr:File:Roquinimex_synthesis.svg
dbp:atcPrefix	L03 (en)
dbp:atcSuffix	AX02 (en)
dbp:c	18 (xsd:integer)
dbp:casNumber	84088 (xsd:integer)
dbp:chebi	92056 (xsd:integer)
dbp:chembl	11672 (xsd:integer)
dbp:chemspiderid	10619239 (xsd:integer)
dbp:drugbank	DB11366 (en)
dbp:eliminationHalfLife	-151200.0
dbp:h	16 (xsd:integer)
dbp:iupacName	4 (xsd:integer) phenyl-1,2-dihydroquinoline-3-carboxamide (en)
dbp:kegg	D05756 (en)
dbp:n	2 (xsd:integer)
dbp:o	3 (xsd:integer)
dbp:pubchem	54676478 (xsd:integer)
dbp:smiles	CN1C2=CC=CC=C2CO (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	SGOOQMRIPALTEL-UHFFFAOYSA-N (en)
dbp:unii	372 (xsd:integer)
dbp:verifiedfields	changed (en)
dbp:verifiedrevid	447995846 (xsd:integer)
dbp:watchedfields	changed (en)
dbp:wikiPageUsesTemplate	dbt:Antineoplastic-drug-stub dbt:Drugbox dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Fdacite dbt:Stdinchicite dbt:Immunostimulants
dcterms:subject	dbc:3-Hydroxypropenals dbc:Carboxamides dbc:Quinolinols dbc:2-Quinolones dbc:Anilides dbc:Immunostimulants
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	Linomide (Roquinimex) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity. It also inhibits angiogenesis and reduces the secretion of TNF alpha. Linomide has been investigated as a treatment for some cancers (including as adjuvant therapy after bone marrow transplantation in acute leukemia) and autoimmune diseases, such as multiple sclerosis and recent-onset type I diabetes. Several trials have been terminated due to serious cardiovascular toxicity. (en)
rdfs:label	Linomide (en)
owl:sameAs	wikidata:Linomide dbpedia-hu:Linomide dbpedia-sh:Linomide dbpedia-sr:Linomide dbpedia-vi:Linomide https://global.dbpedia.org/id/56McG
prov:wasDerivedFrom	wikipedia-en:Linomide?oldid=1120108414&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Roquinimex.svg wiki-commons:Special:FilePath/Roquinimex_synthesis.svg
foaf:isPrimaryTopicOf	wikipedia-en:Linomide
is dbo:wikiPageRedirects of	dbr:Roquinimex dbr:ATC_code_L03AX02 dbr:ATCvet_code_QL03AX02
is dbo:wikiPageWikiLink of	dbr:Roquinimex dbr:ATC_code_L03AX02 dbr:ATCvet_code_QL03AX02
is foaf:primaryTopic of	wikipedia-en:Linomide