About: Mark Mayer

An Entity of Type: animal, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Mark Lee Mayer FRS is scientist emeritus at the National Institutes of Health (NIH). His research investigates glutamate receptor ion channels, the major mediators of excitatory synapses in the brain. He has made numerous observations that have changed our view of receptor function and neurotransmission in the brain. Major findings include discovery of the block of NMDA receptors by extracellular Mg and their high Ca permeability; analysis of the permeation and block of Ca permeable AMPA and kainate receptors by cytoplasmic polyamines; and structural studies on ligand binding, allosteric modulation, and gating using X-ray diffraction and cryoelectron microscopy.

Property	Value
dbo:abstract	Mark Lee Mayer FRS is scientist emeritus at the National Institutes of Health (NIH). His research investigates glutamate receptor ion channels, the major mediators of excitatory synapses in the brain. He has made numerous observations that have changed our view of receptor function and neurotransmission in the brain. Major findings include discovery of the block of NMDA receptors by extracellular Mg and their high Ca permeability; analysis of the permeation and block of Ca permeable AMPA and kainate receptors by cytoplasmic polyamines; and structural studies on ligand binding, allosteric modulation, and gating using X-ray diffraction and cryoelectron microscopy. (en)
dbo:academicDiscipline	dbr:Structural_biology dbr:Ion_channel dbr:Glutamate_receptor dbr:Biophysics
dbo:almaMater	dbr:University_of_Bristol dbr:University_of_London
dbo:award	dbr:Harkness_Fellowship
dbo:birthName	Mark Lee Mayer (en)
dbo:institution	dbr:National_Institutes_of_Health
dbo:thumbnail	wiki-commons:Special:FilePath/Mayer_FRS.jpg?width=300
dbo:wikiPageExternalLink	https://ethos.bl.uk/OrderDetails.do%3Fuin=uk.bl.ethos.484097 https://irp.nih.gov/pi/mark-mayer
dbo:wikiPageID	62290171 (xsd:integer)
dbo:wikiPageLength	5561 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1084404279 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Beit_Memorial_Fellowships_for_Medical_Research dbr:Pharmacology dbr:University_of_Bristol dbr:University_of_London dbc:Living_people dbc:Year_of_birth_missing_(living_people) dbr:Columbia_University dbr:Structural_biology dbr:Emeritus dbr:Harkness_Fellowship dbr:Neurotransmission dbc:20th-century_British_biologists dbc:Fellows_of_the_Royal_Society dbr:Ion_channel dbr:Eric_Gouaux dbr:Fellow_of_the_Royal_Society dbr:Glutamate_receptor dbr:Biophysics dbr:PhD dbr:National_Institutes_of_Health dbr:Society_for_Neuroscience dbr:Neuropharmacology dbr:Excitatory_synapse
dbp:almaMater	dbr:University_of_Bristol dbr:University_of_London
dbp:awards	dbr:Harkness_Fellowship
dbp:birthName	Mark Lee Mayer (en)
dbp:fields	dbr:Structural_biology dbr:Biophysics Glutamate receptors (en) Ion channels (en)
dbp:name	Mark Mayer (en)
dbp:thesisTitle	Inhibitory synaptic mechanisms and transmitter candidates in the rostral hypothalamus of the rat (en)
dbp:thesisUrl	https://ethos.bl.uk/OrderDetails.do%3Fuin=uk.bl.ethos.484097
dbp:thesisYear	1980 (xsd:integer)
dbp:website	https://irp.nih.gov/pi/mark-mayer
dbp:wikiPageUsesTemplate	dbt:Authority_control dbt:Other_people dbt:Post-nominals dbt:Reflist dbt:Use_dmy_dates dbt:Infobox_scientist dbt:FRS_2019
dbp:workplaces	dbr:National_Institutes_of_Health
dcterms:subject	dbc:Living_people dbc:Year_of_birth_missing_(living_people) dbc:20th-century_British_biologists dbc:Fellows_of_the_Royal_Society
rdf:type	owl:Thing foaf:Person dbo:Person dul:NaturalPerson wikidata:Q19088 wikidata:Q215627 wikidata:Q5 wikidata:Q729 dbo:Animal dbo:Eukaryote dbo:Scientist dbo:Species schema:Person wikidata:Q901
rdfs:comment	Mark Lee Mayer FRS is scientist emeritus at the National Institutes of Health (NIH). His research investigates glutamate receptor ion channels, the major mediators of excitatory synapses in the brain. He has made numerous observations that have changed our view of receptor function and neurotransmission in the brain. Major findings include discovery of the block of NMDA receptors by extracellular Mg and their high Ca permeability; analysis of the permeation and block of Ca permeable AMPA and kainate receptors by cytoplasmic polyamines; and structural studies on ligand binding, allosteric modulation, and gating using X-ray diffraction and cryoelectron microscopy. (en)
rdfs:label	Mark Mayer (en)
owl:sameAs	http://viaf.org/viaf/26337191 https://orcid.org/0000-0003-4378-8451 wikidata:Mark Mayer https://global.dbpedia.org/id/B6sgu
prov:wasDerivedFrom	wikipedia-en:Mark_Mayer?oldid=1084404279&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Mayer_FRS.jpg
foaf:homepage	https://irp.nih.gov/pi/mark-mayer
foaf:isPrimaryTopicOf	wikipedia-en:Mark_Mayer
foaf:name	Mark Mayer (en)
is dbo:wikiPageRedirects of	dbr:Mayer,_Mark
is dbo:wikiPageWikiLink of	dbr:List_of_fellows_of_the_Royal_Society_M,_N,_O dbr:List_of_fellows_of_the_Royal_Society_elected_in_2019 dbr:Mayer,_Mark dbr:Mark_Mayer_(disambiguation)
is foaf:primaryTopic of	wikipedia-en:Mark_Mayer