Natallia E. Uzunbajakava, PhD

Yesterday the Royal Society hosted a 'Technological Obsolescence' roundtable which brought together experts from industry, academia and civil society to discuss strategies for combating the technological obsolescence of medical devices and digital assistive technologies (DigAT). The phenomena of technology obsolescence, where existing technologies become outdated and unsupported and patient abandonment, where recipients of medical devices (such as neural interface implants) are left without maintenance or removal options is disheartening. Brilliant recent article by Liam Drew https://lnkd.in/eFydxnsa There will be a forthcoming DDaT Report https://lnkd.in/eKMdmDyU , which will be published soon. Special HUGE thanks to brilliant Michael S Okun, for chairing the discussion.

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Determining the most appropriate diagnostic test for a patient is not always straightforward. Researchers from Amsterdam UMC - Alzheimer Center Amsterdam have published an article on how a computer tool based on artificial intelligence can assist in this process. Together with researchers from Finland, Sweden, Denmark, and Italy, they developed a data-driven method to efficiently and systematically conduct diagnostic tests. Read more: https://lnkd.in/gM6AwVp2

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Unlock the power of global accessibility with DOI! Ensure your research stands the test of time and is easily discoverable. At Twisting Memoirs Publication, we help authors secure Digital Object Identifiers (DOI) for their articles, enhancing visibility and credibility in the scholarly world. #DOI #ResearchVisibility #AcademicPublishing #TwistingMemoirs

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In our latest research, published in the Journal of the Royal Society Interface, we explore the uncertainties in infection exposure predictions based on single-point CO₂ measurements in classroom settings. Led by Carolanne Vouriot from the University of Sheffield and in collaboration with Henry Burridge, this study uses computational fluid dynamics to examine CO₂ dispersion in naturally ventilated classrooms. Our findings highlight how ventilation patterns and sensor placement impact the reliability of CO₂ measurements as indicators of far-field exposure to airborne infections. By simulating various classroom layouts, we observed that while single-point CO₂ measurements can provide useful proxies, their accuracy varies across different airflow configurations, typically remaining within a factor of two of the actual exposure. We argue this uncertainty is small compared with other uncertainties inherent in modelling airborne infection risks. Read the full paper here: https://lnkd.in/em546SRt #IndoorAirQuality #InfectionControl #Ventilation #CO2Monitoring #Research #Imperial #UniversityOfSheffield #CFD #ClassroomSafety

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About Virtual cohort generation and validation with Wouter Huberts e Sabine Verstraeten from Eindhoven University of Technology. #insilicomedicine #insilicoclinicaltrial #SIMCor #virtualcohort #ai #modelling #simulation #science #healthcare #H2020 

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📣 Delighted to share this paper which was a collaborative effort with #UMC Utrecht group Simon Mastbergen,  Mylène Jansen, Goran van der weiden with our Group Miya Marco Yonatan Maatuf and Eli Reich: https://lnkd.in/dQpcgzpN This is an advance from our 2020 ARD paper (PMID: 32665267), which largely focused on the NT/CT Sirt1 serum Biomarker in #preclinical models, which showed increased NT/CT Sirt1 with moderate OA severity. Here, using a knee distraction #KJD cohort, and #imaging (MRI and radiotherapy), we find a significant positive association at baseline for the NT/CT SIRT1 with the appearance of osteophytes and reduction of PIIANP/CTX-II, confirming it may be a predictor #endotype #biomarker of OA severity in clinical samples. NT/CT SIRT1 didn’t display a revered trend after the knee distraction #KJD procedure, which resulted to #structural improvement of the joint. However, a new #detection method aiming to monitor full-length SIRT1 #serum levels displayed an #upward trend (p=0.082)  with reduced denuded bone. The data may indicate that #structural improvement of the joint may be reflected by the #emergence of #flSIRT1 in serum.  While the data are statistically #insignificant, we are very encouraged and will continue to improve the method to monitor additional #OA cohorts. #osteoarthritis #research #ArthritisResearchandTherapy Pls feel free to get in touch if you’re interested in such a collaboration #osteoarthritis #research #biomarker #molecular #endotype COST Action CA21110 - NetwOArk The Hebrew University of Jerusalem OARSI - Osteoarthritis Research Society International

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How can researchers make the design of medical devices more #inclusive? Measuring characteristics of patients correctly can make all the different, e.g. in surgery, because it improves effectiveness of outcomes.   In this episode of our podcast series on #Inclusive #Research and #Innovation (#IRI) in #Science, #Technology, #Engineering and #Mathematics (#STEM), Prof. Dr. Domenico della Volpe from Faculty of Science | University of Geneva shares insights on his research with the host, Dr. Claudia Werker from Delft University of Technology. Both have been working on the ATTRACT EU project: Domenico on the engineering side and Claudia on the business side of the project.   Dominico Della Volpe is a particle physicist with a keen interest in #Radio-Guided Surgery (#RGS) in #nuclear #medicine. In this podcast, he shares his journey developing a new medical device, POSICS-2, for #tumor treatment through RGS, highlighting how the diverse needs of individuals influence the final design of such devices. Domenico stresses both the vital role of #interdisciplinary #collaboration and the need to address #unconscious #biases in research make IRI in STEM happen.   You find our newest podcast on #spotify https://lnkd.in/e3YHuaeY #apple https://lnkd.in/esbEc7yX #google https://lnkd.in/et3rGsVh or can listen to it on your favourite podcasting app. TU Delft | Technology, Policy and Management, Kimberley Gerlach Vasileia Vassou

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Making medical devices more #inclusive. This is what @Dominco della Volpe has been doing. Please listen to our newest podcast on #Inclusive #Research and #Innovation (#IRI) in #STEM.

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Although #wearabletech has become increasingly common, comprehensive studies examining its ownership across different #sociodemographic groups are limited. The aims of this study were to (1) measure #wearabledevice ownership by sociodemographic characteristics in a cohort of #US #consumers and (2) investigate how these devices are acquired and used for #health-related purposes. Methods: Data from the #RockHealth Digital Health Consumer Adoption Survey collected from 2020 to 2022 with 23,974 US participants were analyzed. The sample was US Census–matched for demographics, including #age, #race/ #ethnicity, #gender, and #income. The relationship between sociodemographic factors and wearable ownership was explored using descriptive analysis and multivariate logistic regression. Results: Of the 23,974 respondents, 10,679 (44.5%) owned #wearables. Ownership was higher among younger individuals, those with higher #incomes and #education levels, and respondents living in #urban areas. Compared to those aged 18-24 years, respondents 65 years and older had significantly lower odds of wearable ownership (odds ratio [OR] 0.18, 95% CI 0.16-0.21). Higher annual #income (≥US $200,000; OR 2.27, 95% CI 2.01-2.57) and advanced degrees (OR 2.23, 95% CI 2.01-2.48) were strong predictors of ownership. Living in rural areas reduced ownership odds (OR 0.65, 95% CI 0.60-0.72). There was a notable difference in ownership based on gender and health insurance status. #Women had slightly higher ownership odds than #men (OR 1.10, 95% CI 1.04-1.17). Private #insurance increased ownership odds (OR 1.28, 95% CI 1.17-1.40), whereas being uninsured (OR 0.41, 95% CI 0.36-0.47) or on #Medicaid (OR 0.75, 95% CI 0.68-0.82) decreased the odds of ownership. Interestingly, minority groups such as non-Hispanic #Black (OR 1.14, 95% CI 1.03-1.25) and #Hispanic/ #Latino (OR 1.20, 95% CI 1.10-1.31) respondents showed slightly higher ownership odds than other #racial/ #ethnic groups. Conclusions: Our findings suggest that despite overall growth in wearable ownership, sociodemographic divides persist. The data indicate a need for #equitable access strategies as wearables become integral to #clinical and #publichealth domains. #wearables #medtech #healthequity #digitalhealth #healthcare #fitness #health

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Do you have a reason for using population-weighted centroids when measuring spatial accessibility? Find the reason in this article: https://lnkd.in/erNEWxgF. The new article provides evidence as to why population-weighted centroids should be used over geographic centroids. So, in the analysis, the effects of centroid assessment methods in measuring spatial accessibility were quantitatively tested. The question was why we need to use population-based centroids (population-weighted and population-reference centroids). We suggest that if your study area consists of regular, small-sized polygons that are densely populated, accessibility values using geographic centroids will be similar to those using population-based centroids. However, as is often the case, study areas have irregular, large-sized polygons with a sparsely distributed population. In such cases, the geographic centroids and population-based centroids will produce different outcomes regarding accessibility values and spatial disparities in accessibility.

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https://lnkd.in/etbaYBXV Plectonemically Supercoiled DNA by Job and Theo Odijk Statistical mechanics, Undulatory Electrostatics, Tight bending path integral, Asymmetry of pitch and radius, Comparison with experiment and simulations

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We are proud to share that one of our ventures, MindAffect, has successfully secured €1.1 million in Series A funding to advance its groundbreaking hearing diagnostics technology into the market. Originating from Radboud University, MindAffect is developing an innovative patented brain computer interface (BCI) technology that diagnoses hearing impairments using brain signals. Designed to assist over 1.6 billion people worldwide who face challenges with traditional diagnostic tests, Aurora requires no verbal or physical feedback, making it accessible for infants, young children, and adults with disabilities. The infusion of new capital will be used to fuel the development and upcoming launch of Aurora, which is anticipated for next year. Big congratulations to CEO Jennifer Goodall and the rest of the team for reaching this significant milestone. We look forward to seeing how this technology will continue to impact lives around the globe. Curious to learn more about how MindAffect changes the landscape of hearing diagnostics? Read the full article “Dutch startup tests hearing via brain-computer interface” on The Next Web. You'll find a link in the comments below. #NLC #MindAffect #Impactinvesting #AI #healthtech

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Earth Sciences in the Netherlands today is vulnerable. What administrators see is expensive equipment, as necessary for for example geophysics and geochemistry. What needs to be emphasized is that in depth knowledge of the Earth Sciences is essential for a range of issues, ranging widely from resources and energy transition, via paleoclimatology, to geopolitics. Red Aardwetenschappen #earthsciencematters Vrije Universiteit Amsterdam (VU Amsterdam)

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"besides qualitative methods and computational methods, the methodological approach for analyzing these books could benefit from the inclusion of the people who are closest to this dataset, namely patients and their relatives, as well as those directly affected, such as healthcare professionals." #citizenscience #mentalhealth #publicengagement #patients #methodologies #bigdata #learning

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𝗟𝗶𝗽𝗼𝗖𝗼𝗮𝘁’𝘀 𝗻𝗮𝗻𝗼𝗺𝗲𝘁𝗲𝗿-𝘁𝗵𝗶𝗻 𝗰𝗼𝗮𝘁𝗶𝗻𝗴 𝗺𝗲𝗲𝘁𝘀 𝗺𝗶𝗰𝗿𝗼-𝗿𝗼𝗯𝗼𝘁𝗶𝗰𝘀 🤖 💚 Exiting news! In a recent publication in Nature Communications Engineering, the Surgical Robotics Lab at the University of Twente in collaboration with the University of Waterloo, The German University in Cairo, Radboud University Medical Centre Nijmegen, the Netherlands and LipoCoat present a unique way of using magnetically controlled hemocompatible micro-robots for vascular treatments. In this publication, the untethered magnetic robots effectively demonstrate locomotion in a difficult-to-access target site, navigating through the ex vivo porcine abdominal aorta and reaching the distal end of the renal artery. The usage of hemocompatible materials to manufactur such devices is crucial but also the ability of lowering the potential infection risk in clinical settings! We have previously shown in collaboration with HaemoScan that LipoCoat coated medical devices passed all hemocompatibility tests at levels comparable, if not better, than the negative controls. Additionally, LipoCoat's bio-mimicking coating technology used on the here presented robots caused a protein fouling reduction of 95% and bacteria fouling reduction of over 99 % ! This demeonstrates again the versatile application potential of our technology to tackle several problems which are nowadays more than ever crucial in supporting the safetey and health of patients. Authors: Leendert-Jan W. Lightenberg, Nicole Rabou, Constantinos Goulas, Wytze Duinmeijer, Frank Halfwerk, Jutta Arens, Veronika Magdanz, Roger Lomme, Emily Klein Rot, Colin Nijland, Dorothee Wasserberg, H. Remco Liefers, Pascal Jonkheijm, Arturo Susarrey Arce, Michiel Warlé, Islam S. M. Khalil #publication #robots #microrobotics #coating #healthcare #innovation #infectioncontrol #material #surface

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Machine Learning Optimization Approach to Design Multi-Epitope Marburg Vaccine Construct Read the Article here: https://bit.ly/48RRRWj #Immunoinformatic #Marburgvirus #MolecularDocking #MolecularDynamicsSimulation #VaccineDesign #Viruslikeparticle #biosciences #Nanoparticles #Science #NanoScience #technology #Biology #Bioengineering #Animalbiotechnology #Agriculturebiotechnology #Biochemistry #Bioethics #Bioinformatics #Biopolymer #Cellbiology #Forensicsciences #Immunology #IndustrialBiotechnology #Microbiology #Genomics #Proteomics #PharmaceuticalSciences

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