Matthew Cook

Want to catch bacterial contamination early in your CHO cell cultures? Aber Instruments Ltd's webinar (link below!) explores how conductivity & dielectric spectroscopy can help with real-time monitoring & process automation. https://lnkd.in/eQPxdiGj #WebinarAlert #bioprocess #biotechnology #ProcessAutomation #CellCulture #ContaminationDetection #learning

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**Challenging Times for Pharma CROs** Since January, the preclinical contract research sector has faced significant challenges, with companies like Evotec, Wuxi Apptec, and Gingko Bioworks experiencing a sharp decline in their stock prices, ranging from 60% to 80%. Amidst this downturn, Charles River has managed to maintain stability. It is noteworthy that despite the well-publicized challenges faced by Wuxi Apptec, it has outperformed both Evotec and Gingko Bioworks, which are grappling with their own set of issues. This dramatic decrease in share prices appears to be linked to the broader contraction in big pharma headcount and layoffs. Reduced orders have led to diminished revenue and a slowdown in research activities, raising concerns about a potential vicious cycle for the contract research lab industry.

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Exploring RAS and RAF Target Engagement: Live-Cell Insights into Molecular Specificity 🔎 Check out a new #PromegaNotes article to discover advanced assay technologies, such as live-cell #NanoBRET® TE Intracellular Assays, reshaping the landscape of drug discovery methods and offering biologically relevant models for enhanced research. https://bit.ly/3zEFa3O #CancerResearch #oncology #lifescience

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Since its first application in 1983, the 3-(4,5-dimethyl- thiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, also known as the MTT assay, has become the method of choice for determining cell viability and proliferation. Scientists use MTT assays in drug discovery to screen primary therapeutics and evaluate their antigrowth and toxicity effects on cells. During the assay, the yellow-colored, positively charged MTT reagent crosses the cell membrane, where the cell then metabolizes the chemical into formazan crystals, triggering a visible color change to purple. The darker the purple, the more viable cells within the solution. When automating reagent dispensing for an MTT assay, researchers should consider the following instrument needs: To find out more, click here: https://lnkd.in/ejkgpQNJ #Acceleratescientificdiscovery #MakePipettingMoreProductive #IntegraBiosciences

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https://lnkd.in/eWsz7CcU With over 60 references, The Neospora Antibody Test Kit from VMRD, Inc. and available from 2BScientific Ltd. employs a competitive ELISA technique to detect the presence of Neospora caninum antibodies in serum samples from cattle. 🐝 Exceptional Precision: Evidenced through sensitivity and specificity assessments, ensuring dependable identification of both positive and negative sera. 🐝 Distinct Discrimination: 5% of sera registered within ±5% of the cut-off value, underscoring exact differentiation between positive and negative samples. 🐝 Streamlined Screening: Streamlines the examination of extensive sample sets, as evidenced by the analysis of 4,323 sera with unknown serologic statuses. 🐝 Robust Confidence: Minimal overlap near the cut-off value inspires assurance in the kit's accuracy. For your own research reagents, get in contact at [email protected] with any queries about this ELISA, our products, or anything concerning life science! #petwelfare #neospora #hereforyou

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Congratulations to the Nanocomp team for Commercial Activity of the Year award received at the SSPC, SFI Research Centre for Pharmaceuticals Annual Symposium this week at the University of Limerick. Working with Sarah Hudson on stage 1 of this project was arduous and a drag…as you can see from our faces in the picture below 😃. I mean, you can’t fake that kind of “chemistry”! I loved working with Nanocomp team every day even though they spoke a foreign language to me. I had to learn a whole new field of science from scratch. In every step they patiently taught me the basics, answered my silly questions, and through it all these highly respected and established scientists were always curious and open about what I had to say from the commercial perspective. That is why after a year’s hiatus, I decided to join them again. When I was considering all the opportunities that came my way in the last few months, I prioritized team dynamic and intellectual challange over other factors. Let’s face it, life is not getting any longer. It’s good to know what you need to get you out of bed every day. (Plus I get to say “plasma” in serious sentences a couple of times a week and for a Trekkie that’s reason enough no?!) Nanocomp is a novel solid drug formulation technology that can potentially enable more therapies to reach the market with significant manufacturing efficiencies and a smaller gentler environmental footprint. Considering the number of therapeutic molecules in the pipeline that are poorly water soluble, this is a very worthwhile venture to explore. I’ll spend the next year finalizing the business plan. Congratulations to the Nanocomp team on this award that is a testament to your dedication and hard work on this project: professors kieran hodnett Peter Davern Åke Rasmuson and the young scientists who built up an impressive body of data to support our claims: Ajay Kumar, Promita Bhattacharjee, Marta Bergillos Ruiz and Peuli Ghosh. Many thanks for SSPC, SFI Research Centre for Pharmaceuticals for the award and for investing so much in the supportive environment that allows innovation to thrive. And of course many thanks to Enterprise Ireland for generously funding this project and enabling the Nanocomp team to come together and do more. Majella Maher our EI advisor and partner in crime, thank you for keeping us on the righteous path and enabling this project every step of the way. You should be in this picture. We will miss you dearly as we finish stage 2. #Chemistry! Here we go again (literally and figuratively). And Bravo Nanocomp. #SSPC15 #UL

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NICE already recommended Genedrive as the point-of-care test of choice in its draft guidance before clopidogrel administration in the management of Ischemic Stroke (IS) and Transient Ischaemic Attack (TIA) patients. Really great achievement outperforming the laboratory test with respect to accuracy! #diagnostics #pharmacogenetics #PGx #pointofcare #POCT #stroke #nhs

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Read our latest blog for a succinct overview of LC-MS analysis of targeted protein degraders and their metabolites 👉 https://bit.ly/4f0pQyl #SCIEXPharma #SCIEXforScience #MassSpec #MassSpectrometry

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Happy 19th birthday this week to Dolomite Microfluidics, part of Unchained Labs 🎂. That's also how long I've been in the same #team as our supremo #microfluidics engineer Phil Homewood ❤️ (and we haven't aged a bit)! The mind boggles to think of how many products have been designed, manufactured & sold in that time 👏. The latest instrument being the Unchained Labs Sunbather GMP-ready #lipidnanoparticle producer - part of the #SunnySuite. Imagine the seamless transition of early stage #drugdiscovery thru optimisation then #GMP production without the need for revalidating your process 👍. Check out our Sunny Suite range of LNP synthesis instruments 👇 https://lnkd.in/eDEtPhQn #tribe #nanoparticles #productdevelopment

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Find out the main analytical techniques/platforms currently being used to develop new AAV therapies in our interview with John Cook and Catherine Spickler from Charles River Laboratories. Read the interview here >>> https://hubs.ly/Q02Zyf970

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#NMR for beginners: This Application Note introduces you to the technique of decoupling - very useful, if you want to get more out of your NMR data.🤓 Maximizing the efficiency and effectiveness of #NMR spectroscopy is essential for gaining insights into molecules at atomic resolution. "Decoupling: The Key to High Resolution and Sensitivity in One-Dimensional NMR Spectra" showcases how to optimize NMR spectra for high resolution and sensitivity: https://lnkd.in/drYYFpAQ #MagneticResonance #Spectroscopy #ApplicationNote

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Global Induced Pluripotent Stem Cell (iPSC) Industry Report – Market Size, Trends, & Forecasts, 2024 - https://lnkd.in/esH83uh Today, iPSCs are being utilized across a diverse range of applications, including: Cellular Therapy: iPSCs are being explored in a diverse range of cell therapy applications for the purpose of reversing injury or disease. Disease Modelling: By generating iPSCs from patients with disorders of interest and differentiating them into disease-specific cells, iPSCs can effectively create disease models “in a dish”. Drug Development and Discovery:iPSCs have the potential to transform drug discovery by providing physiologically relevant cells for compound identification, target validation, compound screening, and tool discovery. Personalized Medicine: The use of techniques such as CRISPR enable precise, directed creation of knock-outs and knock-ins (including single base changes) in many cell types. Pairing iPSCs with genome editing technologies is adding a new dimension to personalized medicine. Toxicology Testing: iPSCs can be used for toxicology screening, which is the use of iPSCs or their derivatives (tissue-specific cells) to assess the safety of compounds or drugs within living cells. Tissue Engineering: iPSCs can be seeded onto scaffolds made from biocompatible materials. These scaffolds mimic the structure and properties of the target tissue and can provide a supportive environment for cell growth and differentiation. Organoid Production: iPS cells can be coaxed to self-organize into 3D structures called organoids, which mimic the structure and function of organs. Organoids can be used for studying organ development, modeling diseases, and testing drugs. Gene Editing: iPSCs can be genetically modified using techniques like CRISPR-Cas9 to correct disease-causing mutations or introduce specific genetic changes. These edited iPS cells can then be differentiated into the desired cell type for transplantation or disease modeling. Research Tools: iPSCs and iPSC-derived cell types are being widely used within a diverse range of basic and applied research applications. Stem Cell Banking: iPSC repositories provide researchers with the opportunity to investigate a diverse range of conditions using iPSC-derived cell types produced from both healthy and diseased donors. Cultured Meat Production: iPSCs are being utilized in clean meat production by serving as the cellular foundation for the creation of lab-grown meat. 3D Bioprinting: iPSCs can be directed to differentiate into cell types of interest, such as skin, heart, or liver cells, which are then incorporated into bioinks. Wildlife Conservation and De-extinction Projects: iPSCs are being used in wildlife conservation and de-extinction projects. For example, Colossal Biosciences is using iPSC technology in an effort to achieve woolly mammoth de-extinction. #ipscells #celltherapy #drugdevelopment #research

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🧬Global Induced Pluripotent Stem Cell (iPSC) Industry Report – Market Size, Trends, & Forecasts, 2024 - https://lnkd.in/esH83uh Today, iPSCs are being utilized across a diverse range of applications, including: Cellular Therapy: iPSCs are being explored in a diverse range of cell therapy applications for the purpose of reversing injury or disease. Disease Modelling: By generating iPSCs from patients with disorders of interest and differentiating them into disease-specific cells, iPSCs can effectively create disease models “in a dish”. Drug Development and Discovery:iPSCs have the potential to transform drug discovery by providing physiologically relevant cells for compound identification, target validation, compound screening, and tool discovery. Personalized Medicine: The use of techniques such as CRISPR enable precise, directed creation of knock-outs and knock-ins (including single base changes) in many cell types. Pairing iPSCs with genome editing technologies is adding a new dimension to personalized medicine. Toxicology Testing: iPSCs can be used for toxicology screening, which is the use of iPSCs or their derivatives (tissue-specific cells) to assess the safety of compounds or drugs within living cells. Tissue Engineering: iPSCs can be seeded onto scaffolds made from biocompatible materials. These scaffolds mimic the structure and properties of the target tissue and can provide a supportive environment for cell growth and differentiation. Organoid Production: iPS cells can be coaxed to self-organize into 3D structures called organoids, which mimic the structure and function of organs. Organoids can be used for studying organ development, modeling diseases, and testing drugs. Gene Editing: iPSCs can be genetically modified using techniques like CRISPR-Cas9 to correct disease-causing mutations or introduce specific genetic changes. These edited iPS cells can then be differentiated into the desired cell type for transplantation or disease modeling. Research Tools: iPSCs and iPSC-derived cell types are being widely used within a diverse range of basic and applied research applications. Stem Cell Banking: iPSC repositories provide researchers with the opportunity to investigate a diverse range of conditions using iPSC-derived cell types produced from both healthy and diseased donors. Cultured Meat Production: iPSCs are being utilized in clean meat production by serving as the cellular foundation for the creation of lab-grown meat. 3D Bioprinting: iPSCs can be directed to differentiate into cell types of interest, such as skin, heart, or liver cells, which are incorporated into bioinks. Wildlife Conservation and De-extinction Projects: iPSCs are being used in wildlife conservation and de-extinction projects. For example, Colossal Biosciences is using iPSC technology in an effort to achieve woolly mammoth de-extinction. #ipscells #celltherapy #drugdevelopment #research

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***NEW PRODUCT ALERT*** Do you work in Oligonucleotide development? If so, take a look at Patsnap's revolutionary new tool - our chemical modification search. Chemical modifications are fundamental to RNA therapeutics, and identifying what modifiers are found at various bases is challenging to say the least. How these modifications are described are often highly individualistic, making these incredibly difficult to identify and search for. Patsnap has eliminated this challenge, creating fully standardised modification ontologies, enabling you to quickly search any modification and identify trends to enhance your development. Find out more in the link, or message me for an introduction. #patsnap #oligo #oligonucleotide #RNA #mRNA

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Further your understanding about the fundamental basis of solvent exchange, the basics of a standard HDX-MS experiment, as well as emerging novel experimental advances by reading this Essays in Biochemistry article! #OpenAccess https://ow.ly/CRnX50UBIVL

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Liquid expectations: you have streaming on demand, groceries and traffic info. Why not biological information too? Providing a new approach to rapid plasmid sequencing has been lingering in the capillary/Sanger zone for a long time. The teams at Plasmidsaurus have been shifting this so that their customers can get their data back faster, as complete fragments- all run on Oxford Nanopore Technologies. For me this is great tech but it’s also an illustration of rising user expectations in science. https://lnkd.in/e7Gumy9t

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Progress on ATE2024 is going so well we are adding an extra two tracks to the agenda! Our Web agenda will go live May 1st! #ATE #Advancedtherapieseurope #cellandgenetherapy #ATMPs #Advancedtherapies #celltherapy #genetherapy

🌟 NEW CASE STUDY 🌟 👩‍🔬 Forensic researchers at King's College London are harnessing cutting-edge equipment from Thermo Fisher Scientific to delve into critical #research concerning the detection of #drugs in human samples with suspected acute drug #toxicity. 💡 This partnership, involving the university, Guy's and St Thomas'​ NHS Foundation Trust, and Thermo Fisher Scientific, aims to revolutionize the analysis of #blood samples from patients presenting with acute drug toxicity in the #emergency department (#ED). 🏥 The potential impact? Faster, more precise #detection and #quantification methods for acute drug toxicity that could become routine in hospitals, ultimately improving health outcomes for individuals in the emergency department. https://lnkd.in/enM4VPDb Edward Goucher | Alexandra Graham | Vincenzo Abbate | Paul Dargan

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