Cardiovascular Medicine, University of Minnesota

LHI Lecture April 2, noon: “Alternatively Activated Macrophages Drive an Injurious Para-Inflammatory Response in Heart Failure” Sumanth Prabhu, M.D. Lewin Distinguished Professor and Chief, Division of Cardiology Professor of Pathology and Immunology Washington University School of Medicine More about Dr. Prabhu from the Wash U website: https://lnkd.in/dw8JC-we Location: 1-101 Microbiology Research Facility (MRF) 689 23rd Ave SE, Minneapolis, MN Map: https://lnkd.in/gu3dWwms Webcast @ z.umn.edu/lhi-webcast Learning Objectives: 1. To review the concepts of inflammation and parainflammation in heart failure 2. To define the profile of alternatively activated macrophages in the failing heart 3. To establish the pathophysiological role of alternatively activated macrophages in pathological cardiac remodeling and fibrosis 4. To discuss the potential for therapeutic targeting of alternatively activated macrophages in heart failure

Congratulations to Forum Kamdar, MD, PhD, the 2025 Recipient of the AHA International Visiting Professorship Award. Dr. Kamdar is an Assistant Professor of Medicine in Advanced Heart Failure at the University of Minnesota Medical School, Cardiovascular Division. She is also a researcher for the Lillehei Heart Institute investigating molecular mechanisms of advanced heart failure in neuromuscular cardiomyopathy. More info about Dr. Kamdar: https://lnkd.in/gu92Dp6P

Congratulations to Assistant Professor Andrea Elliott, MD for her nomination and selection for the 2025 UMMC Clinical Education Medical Staff Award! Dr. Elliott received her award at a ceremony February 27th. Dr. Elliott's BIO: https://lnkd.in/gmDHfVQP

Cardiovascular Division Grand Rounds March 25, 2025 | Noon M&M Presentation Michael Blotner, MD Cardiology Fellow Cardiovascular Division University of Minnesota Medical School Location: 299 Variety Club Research Center (VCRC) 401 East River Parkway, Minneapolis, MN Map: z.umn.edu/vcrc *In-person only*

Join us at ACC.25 for ACC Connect! Saturday, March 29th | 5:00 to 7:00pm Eataly 43 E Ohio St, Chicago, IL 60611 - Meet UMN faculty and fellows - Reconnect with UMN Alumni - Learn about our programs Kindly, your RSVP is required RSVP: https://z.umn.edu/a3g5 More info: https://lnkd.in/gyyrW5Gq Questions? Email [email protected]

Join us for the 2025 Erica Martin Lecture! EVENT WEBSITE: https://lnkd.in/gQjdyK5K March 18, 2025 | noon RSVP for in-person attendance. RSVP LINK: https://lnkd.in/gH4-S2h9 Seats are limited to ensure an engaging experience—secure yours today! Lunch will be provided for in-person attendees. The lecture will also be live-streamed. LIVE-STREAM LINK: https://z.umn.edu/8vwh Speaker: Abigail May Khan, M.D., M.S.C.E. Assistant Professor, Division of Cardiovascular Medicine Oregon Health & Science University Associate Chief, Clinical Cardiology OHSU Knight Cardiovascular Institute Location: Room 299 Variety Club and Research Center 401 East River Parkway, Minneapolis, MN 55455

Heart health is snow joke! Drs. Ganesh Raveendran and Demitri Yannopoulos talk to WCCO about taking care of your heart when shoveling snow.

LHI Lecture March 12, noon: “Oxidative Stress and the Cardiac Myocyte Microtubule Cytoskeleton” Melissa Gardner, Ph.D. Professor Genetics, Cell Biology, and Development University of Minnesota More about Dr. Gardner: https://lnkd.in/guntYDyC Location: 1-101 Microbiology Research Facility (MRF) 689 23rd Ave SE, Minneapolis, MN Map: https://lnkd.in/gu3dWwms Webcast @ z.umn.edu/lhi-webcast Abstract: In the failing heart, the cardiac myocyte microtubule network is remodeled, which contributes to cellular contractile failure and patient death. However, the origins of this deleterious cytoskeletal reorganization are unknown. We now find that oxidative stress, a condition characteristic of heart failure, leads to cysteine oxidation of microtubules. Our electron and fluorescence microscopy experiments revealed regions of structural damage within the microtubule lattice that occurred at locations of oxidized tubulin. The incorporation of GTP-tubulin into these damaged, oxidized regions led to stabilized ‘‘hot spots’’ within the microtubule lattice, which suppressed the shortening of dynamic microtubules. Thus, oxidative stress may act inside of cardiac myocytes to facilitate a pathogenic shift from a sparse microtubule network into a dense, aligned network. Our results demonstrate how a disease condition characterized by oxidative stress can trigger a molecular oxidation event, which likely contributes to a toxic cellular-scale transformation of the cardiac myocyte microtubule network.

Listen to UMNCV faculty Jamie Lohr and Bhavadharini Ramu talk about hypertension on MPR news with Angela Davis yesterday! https://lnkd.in/ghNKizbb #UMNProud #UMNheart

CV Division Grand Rounds March 4, noon Zoom link: https://lnkd.in/gbQKMKVU More Info: https://lnkd.in/gvukCpZr "The Role of the Baroreflexin Tachyarrythmias" Mohamed Hamdan, MD, MBA Chief, Division of Cardiovascular Medicine Mildred & Marv Conney Chair in Cardiology Professor of Medicine University of Wisconsin School of Medicine & Public Health Lunch provided for in-person attendees. 299 VCRC 401 East River Parkway Minneapolis, MN 55455 Map: https://lnkd.in/gVQTFDy8 Hamdan Bio: After completing his cardiology training, Dr. Mohamed Hamdan joined the faculty at the University of Texas Southwestern Medical Center. Next, he was recruited to be the associate chief of cardiology and section head for clinical cardiac electrophysiology at the University of Utah-Salt Lake City. In Utah, Dr. Hamdan earned his MBA, was a tenured professor, and held the John & June B. Hartman Research Endowed Professorship. In July 2012, he joined the University of Wisconsin as the chair of cardiology and new chief of cardiovascular medicine. Dr. Hamdan's research focus is on the role of the baroreflex in tachyarrhythmias, including atrial fibrillation. He has also developed an interest in decision support for the diagnosis and treatment of patients who experience loss of consciousness and falls, particularly in the elderly. His research has been supported by foundation grants and R01 funding from the National Institutes of Health. Dr. Hamdan has served as a peer reviewer for the National Heart, Lung, and Blood Institute, the Department of Veterans' Affairs, and the American Heart Association; for the Heart Rhythm Society, he served as a member of the board of trustees. He has published over 100 original research manuscripts and authored over 20 review articles and book chapters. Dr. Hamdan is an elected member of the Association of University Cardiologists, and has been named multiple times to Best Doctors in America.