“David is an extremely dedicated teacher. He devotes himself fully to being a master of the material he teaches, and he responds extremely well to feedback, allowing him to modify his teaching approach to suit his students. Working with David was a genuine pleasure, and having been his student at one point in time, I can say that it has been an awesome experience to see him come from being someone with very little teaching experience to being a talented instructor who molds students into professionals.”
David Fisher
Somerville, Massachusetts, United States
1K followers
500+ connections
About
Hacker. Artist. Deep Learning / Machine Learning. Motorcycles. Burning Man. Ruby. LED…
Activity
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One of the things I love about Paris is the amount of great cinemas. However, it’s sometimes difficult to follow what’s playing at any given…
One of the things I love about Paris is the amount of great cinemas. However, it’s sometimes difficult to follow what’s playing at any given…
Liked by David Fisher
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LEAKED NEWS: I acquired the domain name os .ai for $150,000 (just saw the transaction reported on some online sources). It's the only two character…
LEAKED NEWS: I acquired the domain name os .ai for $150,000 (just saw the transaction reported on some online sources). It's the only two character…
Liked by David Fisher
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Such fun to be a small part of this journey so far, as lead seed investor Engine Ventures (thanks Phil Inagaki) and as a board member through last…
Such fun to be a small part of this journey so far, as lead seed investor Engine Ventures (thanks Phil Inagaki) and as a board member through last…
Liked by David Fisher
Experience
Education
Licenses & Certifications
Publications
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Differential Neuroprotective and Anti-Inflammatory Effects of L-Type Voltage Dependent Calcium Channel and Ryanodine Receptor Antagonists in the Substantia Nigra and Locus Coeruleus
Journal of Neuroimmune Pharmacology
Neuroinflammation and degeneration of catecholaminergic brainstem nuclei occur early in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Neuroinflammation increases levels of pro-inflammatory cytokines and reactive oxygen species which can alter neuronal calcium (Ca+2) homoeostasis via L-type voltage dependent calcium channels (L-VDCCs) and ryanodine receptors (RyRs). Alterations in Ca+2 channel activity in the SN and LC can lead to disruption of normal pacemaking…
Neuroinflammation and degeneration of catecholaminergic brainstem nuclei occur early in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Neuroinflammation increases levels of pro-inflammatory cytokines and reactive oxygen species which can alter neuronal calcium (Ca+2) homoeostasis via L-type voltage dependent calcium channels (L-VDCCs) and ryanodine receptors (RyRs). Alterations in Ca+2 channel activity in the SN and LC can lead to disruption of normal pacemaking activity in these areas, contributing to behavioral deficits. Here, we utilized an in vivo model of chronic neuroinflammation: rats were infused intraventricularly with a continuous small dose (0.25 μg/h) of lipopolysaccharide (LPS) or artificial cerebrospinal fluid (aCSF) for 28 days. Rats were treated with either the L-VDCC antagonist nimodipine or the RyR antagonist dantrolene. LPS-infused rats had significant motor deficits in the accelerating rotarod task as well as abnormal behavioral agitation in the forced swim task and open field. Corresponding with these behavioral deficits, LPS-infused rats also had significant increases in microglia activation and loss of tyrosine hydroxylase (TH) immunoreactivity in the substantia nigra pars compacta (SNpc) and locus coeruleus (LC). Treatment with nimodipine or dantrolene normalized LPS-induced abnormalities in the rotarod and forced swim, restored the number of TH-immunoreactive cells in the LC, and significantly reduced microglia activation in the SNpc. Only nimodipine significantly reduced microglia activation in the LC, and neither drug increased TH immunoreactivity in the SNpc. These findings demonstrate that the Ca+2 dysregulation in the LC and SN brainstem nuclei is differentially altered by chronic neuroinflammation. Overall, targeting Ca + 2 dysregulation may be an important target for ameliorating neurodegeneration in the SNpc and LC.
Other authorsSee publication -
The Influentials: New Approaches for Analyzing Influence on Twitter
Web Ecology Project
Using a new methodology based on the content and responses of 12 popular users, we determined measurements of relative influence on Twitter. We examined an ecosystem of 134,654 tweets, 15,866,629 followers, and 899,773 followees, and in response to the 2,143 tweets generated by these 12 users over a 10-day period, we collected 90,130 responses published by other users.
Other authorsSee publication -
The Iranian Election on Twitter: The First Eighteen Days
Web Ecology Project
The political events that transpired during and after the 2009 Iranian election garnered global attention, particularly due to the purported importance of Twitter. As a platform- independent service for communication, Twitter has become a preferred vehicle to broadcast unfolding events in Iran both within the country and to an international audience. The use of Twitter to communicate about these events is a striking instance of the memetic spread of behaviors and ideas online. Our report serves…
The political events that transpired during and after the 2009 Iranian election garnered global attention, particularly due to the purported importance of Twitter. As a platform- independent service for communication, Twitter has become a preferred vehicle to broadcast unfolding events in Iran both within the country and to an international audience. The use of Twitter to communicate about these events is a striking instance of the memetic spread of behaviors and ideas online. Our report serves as an initial assessment of the Twitter web ecology -- that is, users interacting with their technological environment -- to sketch out the broad anatomy of discourse on Twitter by providing a novel perspective with quantitative data. Our servers continue to collect data, and we plan to publish a follow-up report that comprehensively explores the structure of the events from additional perspectives and depths.
Other authorsSee publication
Courses
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Advanced Legal Issues and Contract Negotiation
MB-405
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Business Leadership and Ethics
MB-301
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Concert and Tour Promotion
MB-391
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Data Management and Statistics
LMSC-251
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Electroacoustic Music Composition
MUS-450/640
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Legal Aspects of the Music Industry
MB-211
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Modular Functions and Signal Flow
EP-223
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Music Publishing
MB-335
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Principles of Business Management
MB-201
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Principles of Financial Accounting
MB-275
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Principles of Marketing
MB-325
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Record Company Operations
MB-331
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Scoring for Strings
CW-341
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Senior Practicum 1 (Heavy Rotation Records)
MB-490
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Senior Practicum 2 (Heavy Rotation Records)
MB-491
Recommendations received
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After seven and half remarkable years, it's time to close my chapter at Customer.io. I'll dearly miss all the colleagues who challenged me, supported…
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Hell ya! Huge shoutout to the entire Ply team for getting PO v1 out. Now, lets make POs smart 🤖. Oh, and we don't upsell you on using POs like…
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I'm hoping that someone (maybe Jason Fried?) will someday tackle the problem of building a "todo list" app for families. Something simple that…
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¯\_(ツ)_/¯ I must have done something to the LI algo and all of a sudden I'm so popular with VCs -- cool & flattering
¯\_(ツ)_/¯ I must have done something to the LI algo and all of a sudden I'm so popular with VCs -- cool & flattering
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Any administration who kills 18F isn’t serious about making government function better; they’re interested in making government malfunction.
Any administration who kills 18F isn’t serious about making government function better; they’re interested in making government malfunction.
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The trades industry is facing a financial squeeze as tariffs and supply chain costs continue to rise. We analyzed some common pricing trends on…
The trades industry is facing a financial squeeze as tariffs and supply chain costs continue to rise. We analyzed some common pricing trends on…
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2.5 years ago I launched Thesis Driven for $0. Since then, we've helped hundreds of students and crossed $1m ARR. I'm going to explain: Why I…
2.5 years ago I launched Thesis Driven for $0. Since then, we've helped hundreds of students and crossed $1m ARR. I'm going to explain: Why I…
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I have some exciting news today! My company, Beamable, has completed its $13.5M Series A fundraising, which was led by BIKRAFT. I recently read…
I have some exciting news today! My company, Beamable, has completed its $13.5M Series A fundraising, which was led by BIKRAFT. I recently read…
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