David Fisher

David Fisher

Somerville, Massachusetts, United States
1K followers 500+ connections

About

Hacker. Artist. Deep Learning / Machine Learning. Motorcycles. Burning Man. Ruby. LED…

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Publications

  • Differential Neuroprotective and Anti-Inflammatory Effects of L-Type Voltage Dependent Calcium Channel and Ryanodine Receptor Antagonists in the Substantia Nigra and Locus Coeruleus

    Journal of Neuroimmune Pharmacology

    Neuroinflammation and degeneration of catecholaminergic brainstem nuclei occur early in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Neuroinflammation increases levels of pro-inflammatory cytokines and reactive oxygen species which can alter neuronal calcium (Ca+2) homoeostasis via L-type voltage dependent calcium channels (L-VDCCs) and ryanodine receptors (RyRs). Alterations in Ca+2 channel activity in the SN and LC can lead to disruption of normal pacemaking…

    Neuroinflammation and degeneration of catecholaminergic brainstem nuclei occur early in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Neuroinflammation increases levels of pro-inflammatory cytokines and reactive oxygen species which can alter neuronal calcium (Ca+2) homoeostasis via L-type voltage dependent calcium channels (L-VDCCs) and ryanodine receptors (RyRs). Alterations in Ca+2 channel activity in the SN and LC can lead to disruption of normal pacemaking activity in these areas, contributing to behavioral deficits. Here, we utilized an in vivo model of chronic neuroinflammation: rats were infused intraventricularly with a continuous small dose (0.25 μg/h) of lipopolysaccharide (LPS) or artificial cerebrospinal fluid (aCSF) for 28 days. Rats were treated with either the L-VDCC antagonist nimodipine or the RyR antagonist dantrolene. LPS-infused rats had significant motor deficits in the accelerating rotarod task as well as abnormal behavioral agitation in the forced swim task and open field. Corresponding with these behavioral deficits, LPS-infused rats also had significant increases in microglia activation and loss of tyrosine hydroxylase (TH) immunoreactivity in the substantia nigra pars compacta (SNpc) and locus coeruleus (LC). Treatment with nimodipine or dantrolene normalized LPS-induced abnormalities in the rotarod and forced swim, restored the number of TH-immunoreactive cells in the LC, and significantly reduced microglia activation in the SNpc. Only nimodipine significantly reduced microglia activation in the LC, and neither drug increased TH immunoreactivity in the SNpc. These findings demonstrate that the Ca+2 dysregulation in the LC and SN brainstem nuclei is differentially altered by chronic neuroinflammation. Overall, targeting Ca + 2 dysregulation may be an important target for ameliorating neurodegeneration in the SNpc and LC.

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  • The Influentials: New Approaches for Analyzing Influence on Twitter

    Web Ecology Project

    Using a new methodology based on the content and responses of 12 popular users, we determined measurements of relative influence on Twitter. We examined an ecosystem of 134,654 tweets, 15,866,629 followers, and 899,773 followees, and in response to the 2,143 tweets generated by these 12 users over a 10-day period, we collected 90,130 responses published by other users.

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  • The Iranian Election on Twitter: The First Eighteen Days

    Web Ecology Project

    The political events that transpired during and after the 2009 Iranian election garnered global attention, particularly due to the purported importance of Twitter. As a platform- independent service for communication, Twitter has become a preferred vehicle to broadcast unfolding events in Iran both within the country and to an international audience. The use of Twitter to communicate about these events is a striking instance of the memetic spread of behaviors and ideas online. Our report serves…

    The political events that transpired during and after the 2009 Iranian election garnered global attention, particularly due to the purported importance of Twitter. As a platform- independent service for communication, Twitter has become a preferred vehicle to broadcast unfolding events in Iran both within the country and to an international audience. The use of Twitter to communicate about these events is a striking instance of the memetic spread of behaviors and ideas online. Our report serves as an initial assessment of the Twitter web ecology -- that is, users interacting with their technological environment -- to sketch out the broad anatomy of discourse on Twitter by providing a novel perspective with quantitative data. Our servers continue to collect data, and we plan to publish a follow-up report that comprehensively explores the structure of the events from additional perspectives and depths.

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Courses

  • Advanced Legal Issues and Contract Negotiation

    MB-405

  • Business Leadership and Ethics

    MB-301

  • Concert and Tour Promotion

    MB-391

  • Data Management and Statistics

    LMSC-251

  • Electroacoustic Music Composition

    MUS-450/640

  • Legal Aspects of the Music Industry

    MB-211

  • Modular Functions and Signal Flow

    EP-223

  • Music Publishing

    MB-335

  • Principles of Business Management

    MB-201

  • Principles of Financial Accounting

    MB-275

  • Principles of Marketing

    MB-325

  • Record Company Operations

    MB-331

  • Scoring for Strings

    CW-341

  • Senior Practicum 1 (Heavy Rotation Records)

    MB-490

  • Senior Practicum 2 (Heavy Rotation Records)

    MB-491

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