“Padova (Italy), 27 April 2015 To whom it may concern: I had the opportunity to interact with Lavanya Adusumill and her research group in Singapore, in the framework of a very productive scientific collaboration, maintained through long-distance exchange of data and Skype-mediated meetings. The collaboration, started in 2013 and still ongoing, is focused on the characterization of a micro-RNA activity during vertebrate neural development. The results of this study will be published soon, with Lavanya Adusumilli as first author of a collaborative paper. Lavanya Adusumilli is one of the most motivated and hard worker junior researchers ever met in my scientific career, and I am proud to recommend her for future applications, where she will surely display her organizational and cultural skills as a promising young scientist. Yours faithfully, Dr Natascia Tiso, PhD - Assistant Prof. - Univ. of Padova, Italy”
About
> Enthusiastic cell and molecular biologist with 10+ years research experience across…
Experience
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Education
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Course work
1. Statistical analysis and data mining
2. Topics of mammalian development and Genetics -
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Licenses & Certifications
Volunteer Experience
Courses
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Advanced Molecular Genetics
BL5223
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Biomedical Information technology
SMA 5304
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Special Topics in Computer Science: Computational systems biology
CS6280
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Statistical theory and Data Mining
15.077
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Topics of Mammalian Development and Genetics
7.82
Projects
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microRNA results in alternative neural cell fates by negatively regulating canonical Wnt pathway
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Identified the function of a microRNA resulting in alternative neural cell fates both in-vitro (human ES cells) and in-vivo by directly regulating the canonical Wnt pathway. Ongoing work is to establish if this could potentially have a therapeutic role in Parkinson's disease.
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Odor receptor transport into olfactory cilia by the heterotrimeric kinesin-2 increases sensory gain in adult Drosophila antenna
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We found that in the OSNs of Drosophila antenna, the OR enrichment into the ciliary outer segment commences beyond 90 hours after-pupa-formation and continues throughout the adult stage at a slow rate, causing gradual increase in the odor induced responses. Homozygous viable mutations in the kinesin-2 motor subunit gene, Klp64D, blocked this olfactory maturation in the adult stage and lowered the rate of OR enrichment, without affecting the microtubule cytoskeleton of the cilia. In addition, a…
We found that in the OSNs of Drosophila antenna, the OR enrichment into the ciliary outer segment commences beyond 90 hours after-pupa-formation and continues throughout the adult stage at a slow rate, causing gradual increase in the odor induced responses. Homozygous viable mutations in the kinesin-2 motor subunit gene, Klp64D, blocked this olfactory maturation in the adult stage and lowered the rate of OR enrichment, without affecting the microtubule cytoskeleton of the cilia. In addition, a recombinant kinesin-2 tail pulled down the endogenous OR47b from adult head extracts. Therefore, we propose that an independent transport by heterotrimeric kinesin-2 localizes the ORs and related proteins into the ciliary outer segment, after the completion of cilia assembly.
Honors & Awards
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Best oral presentation award
Singapore-MIT alliance
Organizations
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Society for Neuroscience
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Recommendations received
2 people have recommended Lavanya
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vishnuvardhanreddy Eda
📢 AI and Continuous Flow Chemistry Unite! 📢 I’m thrilled to share the most awaited development from our team at Dr. Reddy's Institute of Life Sciences Introducing Our Latest Research: “Supervised Machine-Learning Algorithm using Low Data Sets: Flow Chemistry Optimization of the Key Urea Moiety Construction in Larotrectinib.” We’ve seamlessly combined three powerful elements: 1. Artificial Intelligence 🤖 2. Continuous Flow Chemistry ⚗️ 3. Remarkable Results 📈 These elements aren’t separate innovations—they come together as one cohesive force to transform pharmaceutical synthesis. 🔍 Here’s What We Achieved: • AI-Powered Precision: Leveraging machine learning to predict and optimize reaction conditions with minimal data. • Continuous Flow Efficiency: Enhancing reaction control, safety, and scalability. • Outstanding Results: Achieving 98.95% purity for the anticancer drug Larotrectinib with ultrafast kinetics of a stage Why does this matter? This research redefines what’s possible in pharmaceutical manufacturing. Imagine safer, faster, and more efficient drug synthesis—all made possible by the fusion of AI and continuous flow chemistry. A massive thanks to Srinivas Oruganti & team whose dedication and innovation made this possible. Curious to see how we did it? Dive into the full paper and discover the future of drug development. 🔗 Read the full paper here on OPRD https://lnkd.in/gbfg-quT Let’s shape the future of pharmaceuticals together! 🚀 #Innovation #PharmaceuticalResearch #AI #ContinuousFlowChemistry #DrugDevelopment #Research #Teamwork #DRILS #DrReddys #OPRD #Anticancer #Machinelearning #Reaction #Optimization #Frugal #Data
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Mark Hilliard
On on this day in science Indian physicist Chandrasekhara V. Raman was born. He was awarded the Nobel Prize in Physics in 1930 for his work on the scattering of light and the discovery of the Raman effect. This effect is the change in the wavelength of light when a light beam is deflected by molecules. Raman spectroscopy has since become a key tool for chemical characterisation. #science #ramanspectroscopy #Raman #biotech #pharmaceutical #chemistry #Physics #sciencecommunication #scienceandtechnology #India #indianeconomy
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Dr. Ramakrishnan Sethu, Ph.D
🎉 Exciting News! 🎉 I am thrilled to share that I have successfully completed the MIT certification course on AI in Biotech and Biopharma! This comprehensive program, offered by the prestigious Massachusetts Institute of Technology, has provided me with cutting-edge knowledge and skills at the intersection of artificial intelligence and biotechnology. 🔍 Course Highlights: 1. Advanced AI Techniques: Delved into machine learning, deep learning, and data analytics applications in biotech and biopharma. 2. Biotech Innovations: Explored how AI is revolutionizing drug discovery, genomics, and personalized medicine. 3. Real-World Case Studies: Analyzed successful implementations of AI in leading biotech and pharmaceutical companies. 4. Hands-On Projects: Worked on practical projects that applied AI solutions to current challenges in the industry. 5. Expert Insights: Learned from industry leaders and MIT faculty about the future of AI in healthcare and life sciences. 🚀 Key Takeaways: 1. Enhanced Expertise: Gained a deeper understanding of how AI can drive innovation and efficiency in biotech and biopharma. 2. Practical Skills: Developed practical skills in applying AI to real-world problems, from drug discovery to patient care. 3. Networking Opportunities: Connected with a global community of professionals passionate about AI and biotechnology. I am excited to leverage this knowledge and these skills to contribute to advancements in the biotech and biopharma sectors. A huge thank you to MIT for offering such a transformative learning experience! hashtag #MIT hashtag #AI hashtag #Biotech hashtag #Biopharma hashtag #ArtificialIntelligence hashtag #HealthcareInnovation hashtag #ContinuousLearning
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Sandeep Kumar Dhanda, Ph.D.
#NewPublication #Bioinformatics #Correspondence2Me #CellPress My buddy Rahul Kumar, Yanfeng Wang, and I are excited to share that we have published a #commentary on the prediction of #RNA modifications. This commentary highlights a recent publication that explores identifying human mRNA N4-acetyl cytidine sites. This research employs adaptive feature representation learning that enhances the accuracy and efficiency of detecting these crucial modifications. We believe this advancement holds significant promise for the field of #Bioinformatics and RNA biology. American Society of Gene & Cell Therapy
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Amit Yadav
Trayambak Basak and me edited a spcial issue for @ProteomicsIndia journal JPP https://lnkd.in/gfS6h6mf "Deciphering Protein Conversations: A Proteomic Exploration of Protein–Protein Interactions" Dive into the latest advancements in #proteomics and discover how #ProteinProteinInteractions are shaping our understanding of cellular functions. Check out the special issue and our editorial below! #TeamMassSpec #Proteomics #Bioinformatics #PPI #MolecularBiology #PSI 🔗 Special Issue: https://lnkd.in/gezaRwHu Editorial: https://lnkd.in/gRbqZ_bp
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Ramesh Jayaraman
Oral Cancer This poster elegantly illustrates the challenges in treatment of this deadly form of head and neck cancer, how multi-omic approaches can help in detection and identification of different stages, which in turn can help in identifying appropriate therapies for individual patients. What I particularly like about his poster is that is describes the factors for resistance to drugs based on some Hanahan- Weinberg hallmarks, and compares the molecular features of tumours in relationship to different tumor stages. Such educational posters are very useful for creating awareness about cancer. Dr Gargi, Hope we see more posters like this !
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Yugendran T.
Honoring the legacies of two great leaders on this significant day. At Elango Genetics, we are inspired by the principles of truth, peace, and process – values that both Mahatma Gandhi and Lal Bahadur Shastri exemplified in their leadership. These principles guide our scientific endeavors and push us to make meaningful advancements in genomics, diagnostics, and beyond. As we commemorate their vision, we continue to strive for progress that benefits society and drives innovation forward. #GandhiJayanti #ShastriJayanti #TruthPeaceProcess #Genomics #ScientificProgress #ElangoGenetics
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Sumit B.
How do you know if the question that's being asked can be answered? Solution - develop a Mind and we'll see that AI/ML is useful for doing highly repetitive tasks which we hate. We absolutely shouldn't use it to solve cancer, solve the common cold, solve world hunger etc - we should use the human mind for tackling trivial problems like these.
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Dilli Babu
Believe in Yourself, Take Risks, and Never Give Up! Ratan Tata's inspiring journey teaches us: Don't let age hold you back! Ratan Tata took over Tata Group at 21. Courage is key! He transformed Tata Group into a global powerhouse. Innovation is lifeblood! Ratan Tata invested in disruptive startups. Failure is a lesson! He learned from setbacks and kept moving forward. His Quotes that inspire me: 1. Don't worry about being successful; work towards being valuable. 2. Take the risk, or someone else will. 3. I have always been driven by an innate passion to make a difference. Lessons from Ratan Tata's Life: 1. Visionary leadership 2. Courage to take risks 3. Passion for innovation 4. Resilience in adversity 5. Commitment to social responsibility #RatanTata #Motivation #Inspiration #Leadership #Entrepreneurship #SuccessStory #NeverGiveUp #BelieveInYourself
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Ravindra Kumar
We are excited to serve as Topic Editors for the journal Frontiers in Molecular Neuroscience, alongside Drs. Anjali Garg, Vandana Chaurasia, Deepesh Kumar Gupta, Rajan Shrivastava, Manish Kumar. We are curating a Special Issue entitled "Advancing Therapeutics for Alzheimer's Disease and Related Dementias Through Multi-Omics Data Analysis in Ethnically Diverse Populations." This Research Topic aims to underscore the significance of integrating multi-omics data analyses, encompassing genomics, transcriptomics, proteomics, and metabolomics, in unraveling the molecular underpinnings of Alzheimer’s disease and related dementias across diverse populations. We invite researchers globally to contribute their original research, reviews, and perspectives to this endeavor. Collectively, let us strive to deepen our understanding of these complex disorders, embracing the diversity of our investigations and paving the way for more inclusive and effective strategies to combat them. We would be honored to invite you to contribute an original research paper or review article to this special issue. Your expertise and insights would be a valuable addition to our collective understanding and advancement of therapeutics in this crucial area. We look forward to your potential contribution.
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Dhananjay Hasurkar
🌟 New Blog Published on The Vigyan Chronicles 🌟 Regulatory T-cells (Tregs) play a crucial dual role in the immune system. While they are essential for maintaining self-tolerance and preventing autoimmune diseases under normal conditions, tumors exploit these cells to evade immune attacks. In my latest blog, I explore how Tregs become allies of cancer within the Tumor Microenvironment (TME). Tumors recruit and activate Tregs to suppress anti-tumor immune responses, facilitating immune evasion and unchecked growth. These intricate interactions between Tregs and the TME underline the complexity of immune regulation in cancer progression. 💡 Curious to learn more? Read the full article here: https://lnkd.in/dge3xj_V Nabamita Roy Arittrabha Sengupta Nishant Sahdev Let’s discuss the fascinating dynamics of cancer immunology! #cancerbiology #cancerimmunology #blog #scientificwriting #tvc
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Pallavi Surana
Excited to share my paper on a novel method to classify isoform variants into different expression groups. Co-authored with Pratik Dutta and my Mentor Ramana Davuluri ! 📄 Read the paper: https://lnkd.in/gM57uS2Z 🔬 Explore the TransTEx database: https://lnkd.in/gSwPNGNX 📦 Check out the R package: https://lnkd.in/gtBXKj2k Tissue specificity plays a pivotal role in cellular functioning within organisms, influenced by a myriad of factors ranging from transcriptional modifications to splicing changes accounting to only 9% of the total transcripts (coding and non-coding) in the human genome.
6 Comments -
Sumit B.
[1] Knowing right from wrong CORRECTLY. [2] The desire for true equality (that no component of reality may be considered better than any other - different implies neither better nor worse). [3] Impossible to demonstrate fraternity unless personally defined by the need for Equality. [4] To secure freedom from our animal self through Mind (Wisdom) - neatly shifting us away from the love of beating other people into personal betterment whilst supporting other people in their plight to do the same. [5] This is the reward system of the animal and human beings until morality is acquired. It is easy to see Original Sin in evidence - it likes the sound of its own voice, enjoys being the centre of attention, believes itself to be of greater worth than others - and is the default state of 2 or 3 year olds - who're meant to grow a mind with time - rather than arrest (Donald Trump, Boris Johnson, Vladimir Putin, Kim Jong Un. Benjamin Netanyahu - most likely through the form of exclusive 'education' exclusive of education that they've been subject to) in a state (as they have done) of sworn allegiance to violence. Alpha males (animal) derive reward from beating other people. This is Original Sin and characterises ALL people who seek to rise in a hierarchy.
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Julia Quintanilha, PharmD, PhD
Our team is proud to present our most recent publication: 👉 For patients with metastatic colorectal carcinoma, limited RAS pathway testing is standard of care for detection of primary resistance to anti-EGFR mAb therapy. 👉 We empirically evaluate the outcomes associated with a broader set of alterations that would biologically anticipate resistance (ERBB2, RTK, and RAS/PI3K) and found that empirical outcomes associated with these broader alterations similarly associates with limited clinical benefit from anti-EGFR therapy. 👉 Evaluating post-EGFR therapy specimens, we observe a greater prevalence in these alterations as well, temporally consistent with being resistance alterations. 👉 Because these alterations are not included in standard PCR panels, the results suggest greater utility for NGS testing at baseline for clinical decisions around anti-EGFR vs. anti-VEGF use. Ryon Graf, PhD, Matthew J. Emmett, MD, PhD, Samuel Klempner, Samantha Morley, Hanna Tukachinsky, and Alexa Schrock, PhD
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