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Senior Management level, professional with a rare and valuable blend of 12 years…
Articles by Paren
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Label-free Microscale Thermophoresis: Binding of Glutamate to iGluR2, SM to Kinase p38, aptamers to thrombin & Ca(2+) ions to synaptotagmin
Label-free Microscale Thermophoresis: Binding of Glutamate to iGluR2, SM to Kinase p38, aptamers to thrombin & Ca(2+) ions to synaptotagmin
Binding affinities are measured in the native state by taking advantage of the intrinsic fluorescence of proteins. The…
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A step towards the development of systematic prediction and control of protein−NP corona composition: DCS and Microscale Thermophoresis
A step towards the development of systematic prediction and control of protein−NP corona composition: DCS and Microscale Thermophoresis
Nanoparticle Corona Formation using DCS established Fib>>Tif >HSA as the hierarchy for protein adsorption on to Silica…
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MST Signal Amplitude & Protein Polymerization
MST Signal Amplitude & Protein Polymerization
A wealth of information is hidden in a typical MST trace, here the MST signal amplitude is used to determine kinetics…
Contributions
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Your R&D team faces pushback from senior researchers on new methods. How do you address their resistance?
Knowledge earned through experience is invaluable to the R&D team - acknowledge that. The new methods could either be built upon that foundation, or it could be a radically new way of addressing a problem. Knowledge from the past paves the way for innovation in the future, blending wisdom with progress to create a foundation for breakthroughs. Appeal to their Curiosity and Discovery, it is the next logical step in their journey of impact.
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What do you do if your team is not understanding your vision as a leader?
Having recently participated in the rolling out of a strategic mission/vision as part of a team, from a "non-leader" perspective I have to say that what helped me was that the leaders presented the WIFFY "What's in it for you" with great clarity. Knowing the benefits and outcomes of the vision helped the team greatly and motivated them to invest their time, energy, and efforts into realizing the vision.
Activity
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🔬 New Publication in mAbs Journal! 🔬 Excited to share our new paper on computationally designed HC and LC pairing solutions! Our constant domain…
🔬 New Publication in mAbs Journal! 🔬 Excited to share our new paper on computationally designed HC and LC pairing solutions! Our constant domain…
Liked by Paren Patel
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❗📚💡Targeted Protein Degradation by #KLHDC2 Ligands Identified by High Throughput Screening https://lnkd.in/dekTGYxK #TPD…
❗📚💡Targeted Protein Degradation by #KLHDC2 Ligands Identified by High Throughput Screening https://lnkd.in/dekTGYxK #TPD…
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Understanding the features of the surface of viruses that can be targeted by human antibodies is the single most important factor these days in…
Understanding the features of the surface of viruses that can be targeted by human antibodies is the single most important factor these days in…
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I'll be attending the Drug Discovery Chemistry (#DDC2025) conference in San Diego from April 14th-17th, 2025. Let’s chat about how high-throughput…
I'll be attending the Drug Discovery Chemistry (#DDC2025) conference in San Diego from April 14th-17th, 2025. Let’s chat about how high-throughput…
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Are you a startup eager to meet great investors like the ones shown here? Applications to pitch at Investor Day 2025 may be closed, but you can…
Are you a startup eager to meet great investors like the ones shown here? Applications to pitch at Investor Day 2025 may be closed, but you can…
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The Protein Expression Laboratory produced recombinant proteins for an NCATS study that identified inhibitor for NSP14, a target for SARS-CoV-2…
The Protein Expression Laboratory produced recombinant proteins for an NCATS study that identified inhibitor for NSP14, a target for SARS-CoV-2…
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BioConnect DE has officially launched as a powerful new catalyst for workforce development and industry engagement across the First State. Created…
BioConnect DE has officially launched as a powerful new catalyst for workforce development and industry engagement across the First State. Created…
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Congratulations Siyu Chen, Anny Nguyen, Joschka Müller, MUGE MOLBAY, Aditi M., Sahana Sheshachala, Kemal Baskaya, Nathan Adams and Simone Carneiro on…
Congratulations Siyu Chen, Anny Nguyen, Joschka Müller, MUGE MOLBAY, Aditi M., Sahana Sheshachala, Kemal Baskaya, Nathan Adams and Simone Carneiro on…
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James L. Sherley, M.D., Ph.D.
Today, in a workshop by India’s QADVAS University, Asymmetrex@ presented on the impacts accurate stem cell counting is having in stem cell science and medicine. Hear the impacts in this video excerpt: https://lnkd.in/dPM2jq8D; and visit https://lnkd.in/dxCURbV to impact your stem cell work now. REPOST TO SHARE!
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Earthusiastic
Source: (PloS one) ABA receptor antagonism mitigates high-temperature seed germination inhibition, enhancing priming responses in lettuce. Antabactin (ANT) disrupts thermoinhibition, improving germination at elevated temperatures. This approach offers potential agrochemical solutions for climate-related agricultural challenges.
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Seventh Street Development Group
Check out our latest publication on "Structural Features of the Glassy State and Their Impact on the Solid-State Properties of Organic Molecules in Pharmaceutical Systems" in the Journal of Pharmaceutical Sciences. Free download until July 20, 2024. Enjoy the read! https://lnkd.in/ek2bu4Ud
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Bruker BioSpin
In this article, authors Cédric Schaefer, Emmanuel Cornet (both from UCB) and Martial Piotto (#Bruker) discuss the use of high-resolution NMR spectroscopy to characterize the higher-order structure (HOS) of proteins. This approach could help manage product quality risks during the development, manufacturing, and stability studies of mAb therapeutics. Read more: https://lnkd.in/dGvhri8a #NMR #Pharma #PharmaIndustry #HigherOrderStructure #CriticalQualityAttribute
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ALL Chemistry Inc.
#Inhibitors are important for the regulation of chemical processes in the body. Enzymes, proteins that speed up reactions, can be slowed or stopped by using inhibitors. This regulation allows different processes to be turned on or off when necessary. https://lnkd.in/gnMnMb2p
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Kathy Fraser
Malte Lenders and colleagues conclude that the pharmacokinetic profile of pegunigalsidase alfa depends on the presence of neutralizing anti-AGAL antibodies, which result in reduced plasma half-life and peak enzyme activity after infusion. #pegunigalsidase #FabryDisease #Pharmacokinetics #openaccess https://lnkd.in/gt8CCkFS
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Exploration of BioMat-X
😀 Happy reading. 🔥 Title: Navigating regulatory challenges in molecularly tailored nanomedicine ⭐ Authors: Ajay Vikram Singh*, Preeti Bhardwaj, Aditya Kumar Upadhyay, Anselmo Pagani, Jyoti Upadhyay, Jolly Bhadra, Veronica Tisato, Manali Thakur, Donato Gemmati, Rudresh Mishra, Paolo Zamboni 📃 Abstract: Nanomedicine, a convergence of nanotechnology and medical sciences, has unleashed transformative potential in healthcare. However, harnessing the benefits of nanomedicine requires a thorough understanding of its regulatory landscape. An in-depth discussion of regulatory considerations, including molecular safety assessment, harmonization of the regulatory landscape, and shaping the future of innovation, is presented in this discourse. The molecular safety assessment entails evaluating interactions between nanoparticles and biomolecules, ensuring compatibility at the molecular level. Harmonization involves developing international standards and guidelines for a consistent regulatory approach, while shaping innovations emphasizes integrating molecular safety assessments into early stages of development. Challenges encompass the need for standardized assessment methods, balancing innovation with safety, and addressing unique features of novel molecular designs. As the nanomedicine landscape evolves, effective regulatory strategies must navigate the intricate interplay of molecules and technologies, ensuring both patient access and product safety. 💡 Keywords: Nanomedicine, regulatory considerations, molecular safety assessment, harmonization, innovations, patient safety For more? Please read the full text at: https://lnkd.in/gD-___NC #biomaterials #nanomedicine Editorial office: [email protected]
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Department of Chemistry at the University of Toronto
Biological Chemistry MSc Seminar: Come hear Gary Zheng discuss Developing light-switchable affibody based inhibitors of key interactions in the p53 network. June 21st at 2:00 p.m. To learn more, check: https://lnkd.in/g83TEyZA
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Shannon Primavere
Join us Friday November 1, 2024 at 11am EDT for the webinar, to discover how to transform data into achievable insights for optimizing your cell culture process" "Analytical Solutions To Help Accelerate Bioprocessing Success" Key topics include: *Performance Optimization *Metabolite & Lipid Analysis *Customized Analytics *Prototyping for CGMP Register here for free: https://lnkd.in/d_TdSRa9 #cellculture #Bioprocessing #performanceoptimization #lifesciences
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Virtual Lab Inc.
Researchers at Yokohama National University have utilized machine learning and AI to predict the molecular selectivity of chemical reactions, specifically nucleophilic additions to cyclic ketones. By combining AI with chemical knowledge, they analyzed sterics and orbitals to determine how these factors influence reaction outcomes. Their study demonstrated the ability to predict reaction selectivity, enhancing the efficiency of chemical synthesis processes. This approach aims to streamline the development of pharmaceuticals and natural products. For more details, visit the following article on Phys org: https://lnkd.in/etVHYdqS
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