“I worked with Reza while he was completing his Ph.D. at Princess Margaret Hospital. Reza and I collaborated on a few drug discovery projects. Reza is very skillful in high-content microscopy (Cellomics) and invasion/migration assays. He has an exceptional understanding of cancer biology and cell signaling. He is a dedicated worker and a pleasure to work with. I look forward to working with him in the future and recommend him for any position.”
Reza Beheshti Zavareh
San Diego, California, United States
2K followers
500+ connections
About
Over 20 years of experience in cancer biology, immunology, and drug discovery, including…
Activity
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I'm thrilled to share that Abbas Kazimi has been appointed as CEO of @Nimbus Therapeutics! Having worked closely with Abbas, I've witnessed firsthand…
I'm thrilled to share that Abbas Kazimi has been appointed as CEO of @Nimbus Therapeutics! Having worked closely with Abbas, I've witnessed firsthand…
Liked by Reza Beheshti Zavareh
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We are excited to share that Mackenzie Health has officially joined UHN’s Princess Margaret Cancer Care Network. This marks the seventh cancer…
We are excited to share that Mackenzie Health has officially joined UHN’s Princess Margaret Cancer Care Network. This marks the seventh cancer…
Liked by Reza Beheshti Zavareh
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What exactly is Scripps Research? As a nonprofit, leading research institute, we empower scientists to push the boundaries of discovery—advancing…
What exactly is Scripps Research? As a nonprofit, leading research institute, we empower scientists to push the boundaries of discovery—advancing…
Liked by Reza Beheshti Zavareh
Experience
Education
Publications
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JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma
Science
Our results support the therapeutic potential of small-molecule JAK inhibition in combination with checkpoint inhibitors in cancer. We demonstrate that JAK inhibition is not immune suppressive but rather stimulatory, suggesting that the context of JAK inhibitor usage dictates the ultimate treatment outcome. Given that the immunomodulatory properties and clinical efficacy were not exclusive to Hodgkin lymphoma, it will be important to explore the clinical potential of JAK inhibitors with ICI in…
Our results support the therapeutic potential of small-molecule JAK inhibition in combination with checkpoint inhibitors in cancer. We demonstrate that JAK inhibition is not immune suppressive but rather stimulatory, suggesting that the context of JAK inhibitor usage dictates the ultimate treatment outcome. Given that the immunomodulatory properties and clinical efficacy were not exclusive to Hodgkin lymphoma, it will be important to explore the clinical potential of JAK inhibitors with ICI in solid tumors, particularly those in which suppressive myeloid cells correlate with poor response to ICI monotherapy.
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Identification of small-molecule protein–protein interaction inhibitors for NKG2D
Allosteric modulation of the NKG2D receptor dimer/ligand interface.
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Molecular characterization of type I IFN-induced cytotoxicity in bladder cancer cells reveals biomarkers of resistance
Molecular Therapy Oncology
Constitutive activation of the type I IFN signaling pathway is a biomarker for resistance to both transcriptional response and direct cytotoxic effects of IFNα. We present several genes that discriminate between sensitive and resistant tumor cells, suggesting they should be explored for utility as biomarkers in future clinical trials of type I IFN-based anti-tumor therapies
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HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins
Cell Chemical Biology
Using a phenotype-based discovery approach, we have identified that small-molecule HSP90 inhibitors can directly decrease the expression of multiple immune checkpoint proteins, including PD-L1 and PD-L2, at clinically relevant concentrations in vitro and in vivo. These results provide further rationale for exploration of the potential anti-tumor immunity promoting effects of this drug class in the clinic.
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Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase InhibitorsClick to copy article link
Biochemistry
An ultra-high-throughput biochemical campaign was conducted to screen Calibr's ~1 million compound library, aiming to identify novel GOT1 inhibitors. The identified compounds were further utilized to gain insights into the catalytic pocket of the GOT1 enzyme.
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Suppression of Cancer Progression by MGAT1 shRNA Knockdown
PLOS ONE
Our results suggest that partial systemic depletion of MGAT1 in adults may be tolerable and have important anti-cancer effects.
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Today’s Daily Cartoon, by Ali Solomon. #NewYorkerCartoons https://lnkd.in/e57zztMx
Today’s Daily Cartoon, by Ali Solomon. #NewYorkerCartoons https://lnkd.in/e57zztMx
Liked by Reza Beheshti Zavareh
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Protein scavenger inspires new drug design✨ Scientists unveiled an essential step for protein degradation in mitochondria, offering new ideas to…
Protein scavenger inspires new drug design✨ Scientists unveiled an essential step for protein degradation in mitochondria, offering new ideas to…
Liked by Reza Beheshti Zavareh
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I’m thrilled to join my old JNJ team in earnest celebration of a significant milestone: the FDA’s approval of Spravato as a monotherapy for…
I’m thrilled to join my old JNJ team in earnest celebration of a significant milestone: the FDA’s approval of Spravato as a monotherapy for…
Liked by Reza Beheshti Zavareh
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What a week! The Actio team closed out #JPM25 with a great sense of accomplishment from days of productive meetings and making valuable…
What a week! The Actio team closed out #JPM25 with a great sense of accomplishment from days of productive meetings and making valuable…
Liked by Reza Beheshti Zavareh
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Hot off the press at #JPM25! Today Parabilis CEO Mathai Mammen, M.D., Ph.D. presented updates on the clinical progress of our β-catenin:TCF4…
Hot off the press at #JPM25! Today Parabilis CEO Mathai Mammen, M.D., Ph.D. presented updates on the clinical progress of our β-catenin:TCF4…
Liked by Reza Beheshti Zavareh
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We are thrilled to team up in a new and very innovative way with our colleagues at Eli Lilly and Company. We have started a $500M venture fund called…
We are thrilled to team up in a new and very innovative way with our colleagues at Eli Lilly and Company. We have started a $500M venture fund called…
Liked by Reza Beheshti Zavareh
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Excited this paper is out—one of the most exciting projects I’ve ever worked on https://lnkd.in/efajKadi..
Excited this paper is out—one of the most exciting projects I’ve ever worked on https://lnkd.in/efajKadi..
Liked by Reza Beheshti Zavareh
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🎄 🎅 🎁 As the holiday season is already here and we all start to slow down to spend time with our loved ones. ChemoTactics wants to thank all of…
🎄 🎅 🎁 As the holiday season is already here and we all start to slow down to spend time with our loved ones. ChemoTactics wants to thank all of…
Liked by Reza Beheshti Zavareh
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An exciting time for Schrödinger! We've announced initiation of a multi-target collaboration to bring new and impactful medicines forward. Great work…
An exciting time for Schrödinger! We've announced initiation of a multi-target collaboration to bring new and impactful medicines forward. Great work…
Liked by Reza Beheshti Zavareh
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I am NOT ATTENDING the PharmaWorx conference next week, nor will I ever. For the second year in a row, I have had to email the organizers of the…
I am NOT ATTENDING the PharmaWorx conference next week, nor will I ever. For the second year in a row, I have had to email the organizers of the…
Liked by Reza Beheshti Zavareh
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