Sudhir Rao

Join us at the Drug Discovery Biology Strategy Meeting this November 12th in Boston to hear from Anitha Krishnan, Ph.D, Executive Director of Research at Aviceda Therapeutics. Anitha brings over a decade of innovative scientific expertise in biochemical, immunological, and molecular biology techniques. Her work is pivotal in gene therapy and cell transplantation studies, targeting ocular diseases such as Glaucoma and Age-related Macular Degeneration. She has made significant strides in understanding immune responses in neurodegeneration and autoimmune diseases, particularly through her research on microglial and macrophages and the Fas-FasL system. Anitha will be delving into the "Opportunities and Risks in the Preclinical Development of Molecules that Do Not Cross React with Rodents," offering invaluable insights from her extensive experience in advancing therapeutic approaches from discovery through to clinical trials. Don't miss the opportunity to gain from her comprehensive expertise and her knack for leading innovative preclinical research. #DrugDiscovery #BiomedicalResearch #OcularDiseases #PreclinicalDevelopment #BostonEvents #LifeSciences #StrategyMeetings

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PTC was excited to learn, share and collaborate with other leading RNA experts at the recent 7th Annual RNA-Targeted Drug Discovery & Development Summit in Boston, MA, and the RNA at the Bench and Bedside IV conference in La Jolla, CA. Anu Bhattacharyya, Kerstin Effenberger, and Marla Weetall from our research team presented on ways PTC is leveraging its leading splicing platform to identify promising therapies for rare diseases with high unmet need. Learn more about our splicing platform here: https://bit.ly/4fi4w6L

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The #biosecure act is bad legislation and anti-competitive and will force US #biotech companies to abandon strong and honest #CDMO partners without making us more secure. Longstanding, productive drug-discovery collaborations will inevitably be compromised by an ill-conceived initiative — all for short-term political gain. Patients in need of innovative medicines are the ones that will lose out; I urge leaders in the #biotech industry to stand up and be counted in opposition to this proposed legislation.

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In our latest review published on Journal of Experimental Medicine (JEM) | Rockefeller University Press, we explore the evolution of preclinical tumor models focusing on gliomas — among the most challenging and complex tumors. We dive into the history of these models, evaluate their strengths and limitations, and outline an exciting vision for the next generation of models in the current Resolution Revolution era. My deepest gratitude for the visionary guidance of my mentor Howard Fine and the incredible journey we’ve undertaken together. https://lnkd.in/dg5sZUq3

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🎤 uBriGene Presents Exclusive Sessions at SAPA 2024 @Philly CGT Annual Conference 🎤 🚀 We're thrilled to announce our participation at 2024 @Philly Cell and Gene Therapy Annual Conference with two exclusive sessions aimed at revolutionizing the field: 1️⃣ An Innovative Technology for High Yield and More Stable #CRISPR Guide RNA: Discover how our innovative approach of using in vitro transcription (IVT) in producing guide RNA (#gRNA) that can simplify the process while being more cost-effective and free of organic chemicals. Join us to delve into the future of precision gene editing. 2️⃣ How Could CDMO and Technology Innovations Make CGT Affordable: Dive into the intersection #CDMO of and technological advancements with uBriGene. Learn about our strategies to drive down costs without compromising quality or efficacy. Let's explore how cutting-edge technology can make #CellandGeneTherapy more accessible to all. 2024 @Philly Cell and Gene Therapy Annual Conference brings together the innovators and business leaders to foster collaborations and advance cell and gene therapy in the #GreaterPhiladelphia area. 💡 Join #uBriGene to be at the forefront of innovation and collaboration in the dynamic world of cell and gene therapy and let's make cutting-edge cell and gene technology more accessible!

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We look forward to hearing Christine Rothe, CDO of iOmx, speak at the 6th Annual Macrophage-Directed Therapies Summit in Boston on October 2nd. Christine will provide key insights into IOMX-0675, our highly differentiated, fully human, cross-specific antibody targeting LILRB1 and LILRB2. In the presentation, Christine will discuss how IOMX-0675 effectively repolarizes the tumor microenvironment, resulting in potent tumor cell killing both 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰. Also, Christine will highlight IOMX-0675's unique binding profile, which selectively antagonizes the immunosuppressive receptors LILRB1 and LILRB2 while sparing the immuno-activating family members. This differentiation results in superior macrophage repolarization and immune cell activation compared to other antibodies. 🔬   📢 Stay tuned for further updates!   Hanson Wade Group #CancerResearch #Macrophages #immunotherapy #ImmunoOncology

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🎉 Huge congratulations to Orum Therapeutics for their deal yesterday! Vertex bolts on Orum's Degrader-Antibody Conjugate(DAC) conditioning agents to ImmunoGen's ADC conditioner, acquired in March 2023. But what drives Vertex to explore novel conditioner candidates?   Traditional conditioning agents are poorly tolerated and have posed significant challenges for Hematopoietic Stem Cell (#HSC) Cell and Gene Therapies (CGT), such as Vertex's Casgevy. These hurdles are now being addressed by novel, less aggressive conditioners, as above. For instance, companies like Actinium Pharmaceuticals are also advancing novel conditioning agents in this space. Thus, improved conditioning agents will play a crucial role in expanding the application of HSC CGT.   Another critical challenge in HSC CGT is effective #mobilization. Emerging CGTs often require a higher yield of HSCs than conventional HSC transplantation in cancer. When it comes to in vivo approaches, having more HSCs available in peripheral blood will be critical since ex vivo collection and engineering are not feasible. Thus, there is a growing demand for enhanced HSC mobilizers in this evolving field.   Here comes #GPC201, a potential best/fastest-in-class HSC mobilizer currently in phase 2 clinical trials in the US. It is demonstrating superior features for HSC transplantation in multiple myeloma. As the universe of various CGT pipelines expands rapidly, GPC201 is poised to showcase its full potential.   I eagerly anticipate the transformative impact of pairing GPC201 with novel conditioning agents to enhance patients' HSC transplantation experiences.   Curious about GPC201? 👉👉👉 GPCR Therapeutics

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One company optimizing protein conjugates, one company screening for optimal efficacy and therapeutic window of protein conjugates. Well played, #RESIBoston2024 #ADCs #startup #proteinconjugation

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Join Catherine Ulich (Senior Field Application Specialist) and Anthony Kayas (Account Manger) at Discovery on Target in Boston next week📍 Discovery on Target highlights advances in current and emerging “hot” targets and technologies, as well as target validation strategies for the discovery and development of novel therapeutic agents ranging from biologics to small molecules. Cathrine will be speaking at 9am on 1st October about Accelerating Clinical Translation: Harnessing Biology and Technology with Predictive Models 💡 You can also stop by Booth #212 to speak to our team and find out more about our models! 👋 #Newcells #DiscoveryonTarget #PredictiveModels

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If you're in Boston on Dec 10-12, come listen to Chuhern Hwang at Wayfinder Biosciences talk about how to use novel RNA binders for drug discovery!

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Immune-Onc Therapeutics shared Phase 1b trial data on IO-202, our first-in-class anti-LILRB4 antibody, in combination with azacitidine for #CMML. The results are incredibly promising: ✔️ 50% Complete Remission (CR) Rate ✔️ 66.7% Overall Response Rate (ORR) ✔️ Exceptional outcomes in high LILRB4 expression patients (CR: 83%; ORR: 100%) As the CEO of Immune-Onc Therapeutics, I am inspired by the dedication of our team and grateful for the patients and clinical investigators who made this progress possible. These results bring us closer to transforming care for #CMML patients.

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Excited to share a new publication in the Journal of Molecular Therapy which highlights the eShunt®️ Platform as a CNS gene therapy delivery method. Thanks to the teams at UMass Chan Medical School and Tufts Medical Center for your work on this study. "We're very excited about these promising preclinical results, which suggest that the eShunt System delivery approach could provide biopharmaceutical and biotechnology organizations with a minimally invasive method for delivering gene therapies directly to the cortex and brain." #bbb #CNS #drugdelivery #neurovascular #endovascular https://lnkd.in/eeKCGPm7

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How detailed in your MAIT cell analysis???

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Antibiotics are used to treat BV and UTI, but recurrences are common. Antibiotics inhibit or kill the bacteria that cause these conditions, but and they do not prevent recurrence since they do not restore protective Lactobacillus. To address this unmet medical need, Osel developed a proprietary Live Biotherapeutic Product (LBP), called LACTIN-V that contains the protective vaginal strain, Lactobacillus crispatus CTV-05. L. crispatus CTV-05 produces lactic acid and hydrogen peroxide, adheres to vaginal epithelial cells, and antagonizes bacteria associated with BV and uropathogenic E. coli, which is responsible for most UTIs. LACTIN-V has also been shown to reduce preterm birth.

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Affini-T’s Ankit Gupta, Senior Director, Head of Gene Editing, will present “AFNT-212: A Non-Viral Gene-Edited TCR-T Cell Therapy” to industry and academic leaders at the 5th Genome Editing Therapeutics Summit in #Boston today. Learn more about it here: https://bit.ly/3BflF2Q. #CRISPR #GeneEditing #DrugDevelopment #TCells

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Dr. Nina E. Weisser, Director of Preclinical, Multispecific Antibody Therapeutics, recently authored an article published in Drug Target Review discussing the development of trispecific T cell engagers (TriTCEs) with integrated CD28 costimulation. TriTCEs are designed to address the limitations of conventional bispecific TCEs in treating solid tumors by providing balanced T cell activation, leading to potentially more sustainable anti-tumor responses. This innovative approach could significantly advance immunotherapy for patients with difficult-to-treat solid tumors. Access the article: https://lnkd.in/ewRJvPA9

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40 products approved in roughly a decade. There was a 3.44-fold increase in clinical trials involving CGTs between 2004 and 2023 (102 vs. 351 trials, respectively). Five hundred products are currently in the U.S. pipeline, with 10 to 20 new CGT approvals expected in 2025.

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At Vertex Pharmaceuticals, we’re fortunate to work with talented scientists like Leo Vo, a researcher at our Jeffrey Leiden Center for Biologics, Cell & Genetic Therapies in Boston. Leo’s curiosity and drive are central to the groundbreaking gene editing work happening in our labs. From analyzing data, to hands-on experiments, Leo’s team is working to unlock new ways to tackle genetic diseases. Take a look at a day in Leo’s life and an inside look at our science in action! #VertexDayintheLife

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At Vertex Pharmaceuticals, we’re fortunate to work with talented scientists like Leo Vo, a researcher at our Jeffrey Leiden Center for Biologics, Cell & Genetic Therapies in Boston. Leo’s curiosity and drive are central to the groundbreaking gene editing work happening in our labs. From analyzing data, to hands-on experiments, Leo’s team is working to unlock new ways to tackle genetic diseases. Take a look at a day in Leo’s life and an inside look at our science in action! #VertexDayintheLife

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