George van Aken’s Post

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Senior Scientist at Royal Cosun and owner of Insight Food Inside

I proudly present my newest open-access publication demonstrating the application of an in-silico Mechanistic Digestion Model by simulating a number of aspects of protein digestion for liquid and solid meals. Three cases are demonstrated: 1. The post-prandial peak in the rate of appearance of exogenous Leucine in blood plasma, relevant in relation to muscle protein accretion. The simulated results show a delayed and more sustained appearance of casein compared to whey protein, caused by coagulation of casein at low gastric pH, slowing down gastric emptying. 2. The effect of solidity and sedimentation of protein-rich semi-solid food particles in the stomach, delaying gastric emtying compared to liquid gastric behavior of protein formulations, on the progression of sensorially perceived Hunger and Fullness. The reduced emtying rate of the semi-solid formulation lead to more sustained Fullness and a delay in the return of Hunger. 3. The effect of food texture and the presence of protein digestion inhibitors on the digestion, bioavailability and loss to colon of highly digestible protein. The simulation results suggest that the faster gastric emptying of liquid compared to solid formulations lead to a reduced bioavailability and an increased loss to colon for the liquid formulations compared to the solid formulations, and that both increase for increasing protein intake. Estimates are made for the critical amount of consumed protein that may lead to seriously negative health effects caused by protein putrication by and disbiosis of the gut microbiota, suggesting upper boundaries for the safe oral administration of protein in a meal and through protein supplements, which should however be confirmed by human intervention studies. https://lnkd.in/eYpevrqd

George van Aken

Senior Scientist at Royal Cosun and owner of Insight Food Inside

2mo

I feel very sorry to read that open access journal are now seen as low quality, for good reasons, especially since I spent a lot of personal money in two open-source publications and an conference presentation last year. I hope their contents will still be heard and appreciated. https://www.linkedin.com/posts/ucdsun_researchintegrity-openaccess-academicpublishing-activity-7281234221552041984-XkkV?utm_medium=ios_app&utm_source=social_share_sheet&utm_campaign=copy_link

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