Mount Sinai Innovation Partners’ Post

Yi Shi, PhD, and Adolfo Garcia-Sastre, PhD, at the Icahn School of Medicine at Mount Sinai discuss their research regarding an innovative antibody platform aimed at tackling one of the greatest challenges in treating rapidly evolving viruses like SARS-CoV-2. Learn more from ScienceDaily: https://lnkd.in/g4JqKpkV

Yi Shi, PhD, and Adolfo Garcia-Sastre, PhD, at the Icahn School of Medicine at Mount Sinai discuss their research regarding an innovative antibody platform aimed at tackling one of the greatest challenges in treating rapidly evolving viruses like SARS-CoV-2. Learn more from ScienceDaily: https://lnkd.in/g4JqKpkV

Yi Shi, PhD, and Adolfo Garcia-Sastre, PhD, at the Icahn School of Medicine at Mount Sinai discuss their research regarding an innovative antibody platform aimed at tackling one of the greatest challenges in treating rapidly evolving viruses like SARS-CoV-2. Learn more from ScienceDaily: https://lnkd.in/g4JqKpkV

The clonal selection theory (CST) is the centrepiece of the current paradigm used to explain immune recognition and memory. Throughout the past decades, the original CST had been expanded and modified to explain new experimental evidences since its original publication by Burnet. This gave origin to new paradigms that govern experimental immunology nowadays, such as the associative recognition of antigen model and the stranger/danger signal model. -John Gordon (who originally posted article below) Gordon’s always excellent and occasionally critical posts point out what has been suggested by historians generally: The history of Western science confirms the aphorism that the great menace to progress is not ignorance but the illusion of knowledge. - Daniel J. Boorstin #johngordoncancer #johngordonimmunology #danielboorstin

Researchers from Icahn School of Medicine at Mount Sinai have developed an adaptive multi-epitope targeting with enhanced avidity (AMETA) nanobody platform that conjugates potent bispecific nanobodies to a human immunoglobulin M (IgM) scaffold. • AMETA uses a human IgM scaffold with 20+ nanobodies for superior avidity binding • Targets multiple conserved epitopes, boosting antiviral potency over a million-fold • Demonstrates durable efficacy against sarbecoviruses, including Omicron sublineages • Promotes efficient viral cross-linking and spike loss AMETA’s modularity enables rapid, cost-effective production and adaptation to evolving pathogens. Find the study here: https://lnkd.in/g4rxGbGf Study by Yufei Xiang et al.

Two key factors influencing COVID-19 progression have been identified: the S-protein binding function of ACE2 receptors and host cell membrane fluidity. A recent study delved into the effects of a static magnetic field (SMF) on these factors in lung cells. The research, which encompassed in vitro testing with a Calu-3 cell model and in vivo experimentation with an animal model, revealed that a 0.4 T SMF modified S-protein/ACE2 binding and increased membrane fluidity. Noteworthy results included a reduction in alveolar wall thickening in mice upon SMF exposure. These insights shed light on potential non-invasive treatments to alleviate COVID-19 lung damage. Read more: https://lnkd.in/eqGXW2vA

I'm happy to share a recent study from our lab by a talented PhD candidate Camila Ribeiro, published in Cell Death and Disease. It reveals how age-related thymic deterioration impairs T-cell responses, contributing to immunosenescence. The study highlights the role of medullary TECs (mTECs) in preventing autoimmunity through negative selection of autoreactive T cells or their conversion to regulatory T cells, which involves their unique capacity to express tissue-restricted antigens (TRAs). Our findings show that Foxo3 regulates DNA damage response and TRA expression in mTECs, advancing our understanding of immunological tolerance and autoimmunity control. For more details, click the link. https://lnkd.in/dYftRtcK

Expert Talk: "Modulation of Cell Death – Pathways upon Herpes Simplex Virus-1(HSV-1) Infection" Regulated cell death (RCD) plays an important role in the cell processes like cell survival, proliferation, inflammation and innate immune responses to pathogens. Herpes simplex virus 1 (HSV1) has evolved strategies to favour cell survival, effective virus reproduction and escape host antiviral responses. It is well known that transcription factor NFκB is activated in response to HSV-1 infection. However, molecular mechanisms of NFκB signalling in HSV1-infected epithelial cells are not well studied. We try to elucidate the molecular mechanisms underlying antiviral response. We are also understanding virus-induced cell death, with a major focus on mechanisms and signal cross-talks between apoptosis-autophagy-necroptosis. Moreover, how viral proteins and viral miRNAs regulate these decision-making processes between survival and cell death. Date: 25th Oct, 2024 Time: 3:00 PM to 5:00 PM Venue: Seminar Hall, PIAS. Speaker: Dhairya Rajguru , Doctoral Researcher, Institute of Molecular Medicine and Cell Research, University Medical Hospital Freiburg, Germany. Co-ordinator, jayvadan vaishnav Assistant Professor, Department of Life Sciences Parul Institute of Applied Science Parul University. #lifesciences #pias #paruluniversity

“These DNA fibers, known as neutrophil extracellular traps (NETs), originate from the nuclei of another type of immune cell, neutrophils. NETs are released into the blood in large quantities by highly activated neutrophils after a stroke or heart attack and can directly kill plasma cells in the intestine. A probable even more important effect of NETs is the formation of hundreds of small clots in the blood vessels that supply energy to plasma cells in the intestine. This results in a lack of nutrient and oxygen supply and the Ig-forming cells die off in large numbers. The immunologists and their teams not only succeeded in proving a causal link between stroke, heart attack and immunodeficiency, but they were also able to demonstrate a new treatment approach: If the NETs were destroyed with the enzyme DNase or their release was prevented by a substance with a novel mode of action, the immune defense remained intact. The researchers were able to demonstrate this both in the mouse model and—in the case of DNase—in later clinical studies.” #stroke #cardiovasculardisease #heartattack #immunodeficiency #clots

Excited to share our paper published in Nature Communications after four years of work‼ Rebeca Martínez, Pablo Sacristán-Gómez and me, Nuria Sánchez de la Blanca Carrero, as co-first authors in Fundación para la Investigación Biomédica del Hospital Universitario de La Princesa, used spatial transcriptomics to reveal new molecular signatures and pathological subpopulations of cells in autoimmune thyroid diseases. 🔎 This project was in collaboration with Holger Heyn's and Fatima Sanchez-Cabo's groups. 💻 #spatialtranscriptomics #scRNAseq #thyroid #autoimmunity 📌 https://lnkd.in/e73hD2eR