Neuroimaging techniques have been essential in clinical #neuroscience for decades but have yet to make a significant impact on psychiatric drug development and clinical care. By integrating neuroimaging into precision psychiatry, we can measure drug effects on the brain early to refine dosing and indications and use it in later trials to identify likely responders. This approach has the potential to enhance drug development success, diversify mechanisms, and improve clinical outcomes. In a recent Nature publication, researchers take an industry lens to examine the opportunities and challenges in using #neuroimaging to mitigate risks in drug development and improve clinical efficacy in psychiatric practice, ultimately paving the way for more precise and effective treatments. See here: https://lnkd.in/dUQYTwni
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Understanding Serotonin Agonists and Antagonists in Clinical Practice Here’s a quick guide to serotonin antagonists and agonists, including key drugs, mechanisms of action, clinical effects, and potential side effects. Serotonin plays a crucial role in various physiological processes, and manipulating its pathways can help treat conditions like migraines, schizophrenia, and nausea from chemotherapy. Highlights: Antagonists like ketanserin and ondansetron provide relief in conditions such as hypertension and nausea by inhibiting serotonin receptors. Agonists like sumatriptan target migraines by reducing vascular edema in the brain. Understanding these mechanisms not only improves patient care but also offers insights into managing complex cases in neurology, psychiatry, and gastroenterology. If you’re a healthcare professional or researcher interested in neuropharmacology, this is a snapshot of the practical applications of serotonin-modulating drugs.
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This paper, from a team pioneering the thoughtful use of biomarkers in psychiatric drug development, outlines the potential for imaging-based data to de-risk specific critical points in the process. They make the strong case for committing to prospective, rather than retrospective, biomarker development, as the path forward towards meaningful precision psychiatry. https://lnkd.in/eDr5Z83K
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Biomarkers in psychiatry are greatly lacking relative to other therapeutic areas. I mean, you just can’t cut open or biopsy the brain... Furthermore, the connection between liquid biomarkers and neurological function or dysfunction are highly complex and heterogenous within patient groups. The best tools being employed to understand drug effects in psychiatry are neuroimaging techniques. These pharmacodynamic measurements in neuropsychiatry are relatively new but evidence is growing that including this data collection in early phase trials can greatly de-risk further development of a drug candidate. One of the pioneers of this work, Amit Etkin and Alto Neuroscience, recently published a review on this topic. The future of precision psychiatry heavily relies on this neuroimaging data and interpretation of data into specific patient populations. PET imaging relies on radioligand displacement to determine occupancy on a receptor target of interest. This dynamic relationship between ligand and drug does add some complexity not least making sure there is a radioligand designed for your target; if not this requires considerable R&D costs. Large patient Ns are not required for meaningful data collection. EEG and fMRI measure functional brain changes without the granularity of the molecular interaction of PET imaging. These functional measures along with tasks (eyes open vs closed, cognitive, etc) can provide insights into efficacy or reducing side effects, arguably much better than PET. Generally, larger Ns are needed to confirm these functional imaging techniques between patient dosing groups. However, EEG is relatively cheap and accessible to employ in large trials of patients with standardized protocols and growing effectiveness in pivotal trials. There are now proven cases of this precision approach in FDA approved drugs (i.e. Zuranolone for PPD and Aduhelm for AD). While the commercial viability of these aforementioned drugs remains in question, it’s easy to see the utility of a #precisionpsychiatry approach to increase clinical viability and reduce risks of a development candidate. I believe the next couple of decades will be a golden era in neurology and psychiatry. Just as oncology shifted into a precision or genetic approach (still TBD in psychiatry), I believe we will see a similar and successful approach towards the brain. #sciencesunday https://lnkd.in/e4y47SQr
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📣 We are happy to announce that paper “Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability” co-authored by Jakub Mieczkowski, PhD and Adrian Perdyan, MD has just appeared in Molecular Psychiatry (IF=11.0). 🔬 In the published study the authors showed that selective serotonin reuptake inhibitor (SSRI) and selected representatives of other antidepressants bidirectionally regulate fluid-phase uptake at therapeutic concentrations and below. They characterized membrane trafficking induced by a canonical SSRI fluvoxamine and revealed that it involves enhancement of clathrin-mediated endocytosis, endosomal system, and exocytosis. The findings indicate the modulation of membrane trafficking by antidepressant drugs as a possible cellular mechanism of action and suggest their clinical repositioning potential for regulating drug delivery to the brain. 🤝 The paper is the result of the cooperation of Jakub with Oleg Glebov from Institute of Psychiatry, Psychology & Neuroscience, King's College London. Jakub and Adrian were involved in the analysis and interpretation of RNA sequencing data. ➡️You can read full article at https://lnkd.in/g66mxZCa
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Our perspective article on the epigenetic mechanisms of rapid-acting antidepressants affecting neuroplasticity, neurotransmission and immunity, was just published in Translational Psychiatry! Could epigenetic mechanisms mediate their rapid and sustained therapeutic effects? https://lnkd.in/ePqiBdB9
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We’re excited to announce our partnership with Neuronostics to revolutionize clinical trials with integrated EEG solutions. Together, we are delivering faster, smarter, and more impactful results for pharmaceutical companies, CROs, and academic researchers. This collaboration is a game-changer for neurology and psychiatry research, driving better outcomes for patients worldwide. The future of clinical trials starts now! 🧠 #Partnership #ClinicalTrials #EEG
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Biased agonists are an exciting area of research in modern neuropharmacology, offering significant potential for new therapeutic advancements in neurology and psychiatry. In our recent review published in open-access, we explore their applications in serotonergic neurotransmission, highlighting their potential to transform the field. https://lnkd.in/dzMtDdTU Adrian Newman-Tancredi Centre de Recherche en Neurosciences de Lyon - CRNL Recherche en santé HCL Université Claude Bernard Lyon 1
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Precision Psychiatry: Will novel biomarkers drive progress? 👉 The use of biomarkers holds the potential to revolutionize personalized medicine in the realm of psychiatric disorders. This innovation mirrors the advancements seen in cancer therapeutics, particularly through patient-specific treatments. 👉 This week, Circular Genomics unveiled MindLight, a circular RNA biomarker-based assay designed to predict patient responses to SSRI treatment for depression. SSRIs, being a commonly prescribed class of antidepressants, are often the initial choice for psychiatrists due to their effectiveness and safety compared to older antidepressant classes. 👉 Interestingly, while SSRIs are widely prescribed for their efficacy and safety, only 41% of patients experienced a clinical response. This suggests that the remaining 59% may benefit from alternative medication options. 👉 While genetic biomarkers' utility in treatment decisions for psychiatric disorders remains uncertain, the development of precise biomarkers and enhanced clinical trial methodologies could pave the way for the next era of antidepressant drug development. #eosintelligence #pharmaceuticals #biotech #psychiatry #neurology
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We are thrilled to announce the successful completion of our pivotal clinical trial for the treatment of Major Depressive Disorder! This study marks a historic milestone as the first-ever Randomized Controlled Trial (RCT) to demonstrate success in a non-pharmacological home therapy for Treatment Resistant Major Depression. The success of this pivotal trial not only demonstrates the efficacy and safety of our groundbreaking brain neuromodulation technology but also highlights its transformative potential in revolutionizing depression and mental health treatment. And as Dr. Mark George, distinguished professor of psychiatry, radiology, and neuroscience and director of the Medical University of South Carolina (MUSC) Brain Stimulation Division, said: “This is a great day for patients with depression”. https://lnkd.in/dzi67unx #MentalHealth #DepressionTreatment #Innovation #ClinicalTrial #MentalHealthRevolution#BrainNeuromodulation#
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We’re excited to share a recent feature on Circular Genomics in Springer Nature and Biopharma Dealmakers discussing our latest breakthrough in precision psychiatry, titled “Bringing Precision Medicine to Psychiatry: Circular RNAs as a Window into the Brain.” This article highlights our development of the world’s first circular RNA-based diagnostic, MindLight™, designed to predict patient response to selective serotonin reuptake inhibitors (SSRIs). By analyzing circular RNA from a blood sample, MindLight™ provides unique insights into individual genetic response profiles, facilitating tailored, effective treatment plans. Read the article here: https://lnkd.in/gfZ7XhXK
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