Pearl Smith’s Post

Ophthopedia Update:Oculomics analysis in multiple sclerosis: Current ophthalmic clinical and imaging biomarkers: Eye, Published online: 10 June 2024; doi:10.1038/s41433-024-03132-yOculomics analysis in multiple sclerosis: Current ophthalmic clinical and imaging biomarkers #Ophthalmology #Eye #Ophthotwitter

An informative webinar of imaging biomarkers organized by the European Society of Radiology. Imaging biomarkers are measurable indicators derived from medical imaging techniques that provide information about the biological processes, disease progression, or therapeutic response. These biomarkers play a crucial role in clinical research, diagnostics, and personalized medicine. #ESR #ESOR #EuropeanSocietyofRadiology #EuropeanSchoolofRadiology

𝐂𝐨𝐦𝐩𝐫𝐞𝐡𝐞𝐧𝐬𝐢𝐯𝐞 𝐏𝐃𝐅 𝐆𝐮𝐢𝐝𝐞 𝐭𝐨 #Molecular Imaging Get Free Sample link 👉: @ https://lnkd.in/dAuz-vf2 #MARKET_SEGMENTATION The global Molecular Imaging market is segmented on the basis of technology, application and end user. Based on technology the market is segmented into Gamma Camera, Single Photon Emission Computed Technology, Positron Emission Tomography, Magnetic Resonance Spectroscopy, Optical Imaging, Molecular Ultrasound Imaging. Based on application the market is segmented into Cancer, Heart Disease, Brain Disorders, Gastrointestinal Disorders, Lung Disorders, Bone Disorders, Others. Based on end user the market is segmented into Hospitals, Diagnostic Imaging Centers, Others. #MolecularImaging #MedicalImaging #PrecisionMedicine #Biomarker #Radiolog #ImagingTechnology #Theranostics #HealthcareInnovation #NuclearMedicine #CancerImaging

💡 Application in the spotlight!   In this study by Zhang et al. of the Department of Radiology, University of Chicago, nicotinic receptor membrane-permeant ligands were radiolabeled and evaluated by dynamic PET-CT, combined with kinetic modeling, to investigate how these ligands distribute in the brain, an important question in nicotine addiction.   By combining in vitro and in vivo imaging, the researchers mapped both brain-wide and subcellular distributions of nicotinic receptor ligands, which provided useful information on nicotine addiction.   The β-cube (PET) and X-cube (CT) were used to measure the binding kinetics of α4β2R ligands in vivo, using [18F]2-FA and [18F]Nifene for brain PET imaging in mice.   🔗 Link to the application can be found in the comments!   #PreclinicalImaging #PreclinicalResearch #SPECT

bismuth have high atomic number and favorable X-ray attenuation properties. While they are not as widely used as traditional iodine or gadolinium-based agents, they have significant potential in applications such as CT imaging, dual-energy CT, and even radiotherapy enhancement. Challenges to Overcome Most bismuth-based agents are still in the research or preclinical stage. Developing nanoparticles with optimal size, stability, and biocompatibility is a challenge. Bismuth is less commonly used in clinical settings, requiring investment in production and development. Radiation Scatter: High atomic number materials like bismuth can cause scatter in CT imaging, requiring careful optimization. Future Outlook The future of bismuth-based contrast agents lies in their integration with emerging technologies such as AI-driven imaging analysis and theranostic platforms. As research progresses, these agents could offer safer and more effective options for patients requiring advanced diagnostic or therapeutic intervention

🫀 #cardiomyocytes "Quantitative label-free digital holographic imaging of cardiomyocyte optical volume, nucleation, and cell division" 🔍📄 https://lnkd.in/giSsmq-k 🔬 HoloMonitor was used for quantitative label-free 3D tracking of cardiomyocyte and non-cardiomyocyte dynamics in vitro. #mondayread 📄 ABOUT • Digital holographic imaging enables quantitative label-free 3D monitoring of primary cardiac cultures in vitro. #celltracking • Primary cardiomyocytes can be readily distinguished from non-cardiomyocytes based on their larger size and slower #cellmotility. • Mononucleated and binucleated cardiomyocytes reach a common size-increase threshold prior to #celldivision. ✅ RESULTS CHAPTERS 1. Primary cardiomyocytes are distinguished from non-cardiomyocytes based on their larger size and limited motility 2. Digital holographic imaging permits quantitative tracking of cardiomyocyte optical volume dynamics with single-cell resolution 3. Cardiomyocytes stimulated with CHIR99021 undergo both successful and failed attempts at cell division 4. Binucleated cardiomyocytes exhibit a blunted proliferative response but retain significant capacity for successful cell division 5. Mononucleated and binucleated cardiomyocytes reach a similar size-increase threshold prior to attempted cell division 6. The timing of attempted cell division is slightly delayed in binucleated cardiomyocytes Congratulations to Herman Huang, Sangsoon Park and their colleagues 👏 ➡️ Check out the HoloMonitor experimental #setup in 'Figure 1A' ➡️ Find more time-lapse videos 🎥 in the supplementary data 🎥 MOVIE S6 Example outcomes observed in binucleated rat cardiomyocytes stimulated with 5 μM CHIR99021 for 48 h. Time-lapse videos of representative binucleated cardiomyocytes that complete (left), fail to complete (middle), or do not attempt cell division within 48 h (right). 1 s = 6 h; timestamp, hours:minutes. #HoloMonitor #QPI #publication

Vincent Geest et al. compared edema volume (EV) and midline shift (MLS) as imaging biomarkers of ischemic edema and predictors of malignant infarction and very poor clinical outcome in the early follow-up of CT patients with large infarcts, finding that EV may be an accurate and direct quantitative imaging biomarker when assessing ischemic brain edema in infarcts of all sizes. #EuropeanRadiology 🔗 https://buff.ly/3QjGTRB

Cholangiocarcinoma (CCA) is a type of cancer that forms in the bile ducts, and can occur anywhere along the bile ducts, both within the liver (intrahepatic) and outside the liver (extrahepatic). Traditional methods have limitations in visualizing the full extent of CCA. Our innovative approach using internal receivers for intraductal magnetic resonance imaging (MRI) with T2 mapping has the potential to change the game! What makes it so special? Enhanced local signal-to-noise ratios, precise tissue characterization, and improved visualization - Plus, higher resolution imaging for sharper insights! ✨ 💪 Together, let's keep pushing boundaries and making strides in medical imaging! 🌟💙 Check out the full paper below.  #CancerResearch #Innovation #oncologyimaging https://lnkd.in/ek5tquqn

The deployment of highly sensitive digital pathology biomarkers for fibrosis in MASH clinical trials can accurately reveal the true effect of an intervention, such as resolving changes within categorical stages,....while also identifying new sources of noise! One significant source is intra-liver biopsy variability. Our recent abstract, presented at EASL last week, established that the average coefficient of variability for our Ph-FCS fibrosis biomarker is 7% (mean value, 17 patients, 3 to 4 virtual biopsies). We used retrospective large wedge biopsies (several cm²) to generate virtual biopsies mimicking the trajectory of a 16G needle, an approach invented and previously used by Pr. Bedossa. The image below illustrates the method. The panel on the left shows an extreme case where the machine is confused by highly fibrotic non-contributory features. As with any instrumental approach used in end-to-end tissue assays, collaboration between pathologists and AI methods is essential to achieve maximum performance. The use of highly sensitive digital pathology biomarkers in NASH studies will requires novel paradigms for powering and analyzing such studies. #fibrosis #DigitalPathology #MASH