🧪 Inside Recursion’s analytical chemistry lab. Chad Bradford, Senior Director of Chemistry, shares Recursion’s approach to quickly generating chemistry insights – in vitro data – for drugs in development. ▫️ ADME is a well-known acronym in drug discovery for: absorption, distribution, metabolism and excretion. It tells us what happens to a drug once it goes into the body, how it is processed, and whether it is safe. ▫️ At Recursion, we call our process RADME (the “R” is for Recursion). Our RADME module is highly automated and precise and it is capable of screening hundreds of compounds a week to produce large quantities of relatable data – meaning results are consistent and can be reliably compared across days, weeks, months, and years. ▫️ This system includes a liquid handling robot, a mass spectrometry system, automated pipetting, and a suite of three different assays run at high scale that tell us about a compound’s drug-like properties: metabolic stability, protein binding, and a permeability assay called PAMPA (parallel artificial membrane permeability assay). ▫️ “What stands Recursion apart,” says Chad, “is the amount of data we can generate via the automated throughput, the high quality of the data that we are generating, and the relatability of the data that we are generating,” all of which allows us to quickly screen compounds at a very early stage in the drug discovery process.
Incredible 🤩 great work Chad and team
Very cool! Great work.
Love this. finally out to the public. great design by an amazing team 😉
Love to see how everything works on the inside!
PhD, Scientist, Cancer Research, Nanomedicine, Omics, AI
6dInspiring!