Histone bivalency in CNS development
- 1Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10065, USA;
- 2Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia
- Corresponding authors: hatten{at}rockefeller.edu, kart.matlik{at}taltech.ee
Abstract
Neuronal maturation is guided by changes in the chromatin landscape that control developmental gene expression programs. Histone bivalency, the co-occurrence of activating and repressive histone modifications, has emerged as an epigenetic feature of developmentally regulated genes during neuronal maturation. Although initially associated with early embryonic development, recent studies have shown that histone bivalency also exists in differentiated and mature neurons. In this review, we discuss methods to study bivalency in specific populations of neurons and summarize emerging studies on the function of bivalency in central nervous system neuronal maturation and in adult neurons.
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Article published online ahead of print. Article and publication date are online at http://www.genesdev.org/cgi/doi/10.1101/gad.352306.124.
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Freely available online through the Genes & Development Open Access option.
This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
